Roberts L K, Krueger G G, Daynes R A
J Immunol. 1985 Jun;134(6):3781-4.
A direct correlation between the induced expression of Ia by the host keratinocytes and the infiltration of donor Langerhans cells (LC) into the epidermis was demonstrated in athymic (nude) BALB/c mice that received an adoptive transfer of lymphoid cells from normal semi-syngeneic donors. Neither keratinocyte expression of Ia nor donor LC movement into the epidermis was observed in BALB/c recipients of lymphoid cells from allogeneic C3H nude mice. Further evidence for this relationship was provided by experiments in which the keratinocytes of BALB/c nude mice were induced to express Ia by the injection of normal mouse serum (NMS). By this procedure it was shown that LC precursors derived from allogeneic C3H nude donors were able to infiltrate the epidermis when adoptively transferred into BALB/c nude recipients whose keratinocytes had been induced to express Ia by the simultaneous injection of NMS. These findings suggest that keratinocytes through their expression of Ia may function to facilitate the movement of LC into the epidermis.
在接受来自正常半同基因供体的淋巴细胞过继转移的无胸腺（裸）BALB/c小鼠中，证实了宿主角质形成细胞诱导的Ia表达与供体朗格汉斯细胞（LC）向表皮的浸润之间存在直接相关性。在接受来自同种异体C3H裸鼠的淋巴细胞的BALB/c受体中，未观察到角质形成细胞Ia的表达或供体LC向表皮的移动。通过向BALB/c裸鼠注射正常小鼠血清（NMS）诱导其角质形成细胞表达Ia的实验，为这种关系提供了进一步的证据。通过该程序表明，当将来自同种异体C3H裸鼠供体的LC前体过继转移到通过同时注射NMS诱导其角质形成细胞表达Ia的BALB/c裸鼠受体中时，它们能够浸润表皮。这些发现表明，角质形成细胞通过其Ia的表达可能起到促进LC向表皮移动的作用。
