Daynes R A, Emam M, Krueger G G, Roberts L K
J Immunol. 1983 Apr;130(4):1536-9.
During the course of experimentation designed to evaluate the migration of host Langerhans cells (LC) into normal skin grafted onto nude mice, we observed that the epidermal cells of these grafts were induced to express la determinants solely of graft origin. The data presented herein indicate that the expression of la by normal epidermal cells correlates with the infiltration of host LC into the graft. This la expression is restricted to the keratinocytes within the epidermis of the grafted skin, is first observed 7 to 9 days post-grafting, and persists within the grafted skin for greater than 12 wk. The induction of la expression by keratinocytes appears to be the result of the environment that is provided by the nude mouse host and is independent of both passenger lymphocytes within the skin graft and allogeneic differences between graft and host. We strongly believe that these studies provide the basis for the development of an experimental animal model system for investigating the potential role that la expression by epidermal cells may play in enhancing the immune response to antigens encountered in the skin.
在旨在评估宿主朗格汉斯细胞（LC）向移植到裸鼠身上的正常皮肤迁移的实验过程中，我们观察到这些移植皮肤的表皮细胞被诱导仅表达移植来源的Ia决定簇。本文提供的数据表明，正常表皮细胞Ia的表达与宿主LC向移植皮肤的浸润相关。这种Ia表达局限于移植皮肤表皮内的角质形成细胞，在移植后7至9天首次观察到，并在移植皮肤内持续超过12周。角质形成细胞Ia表达的诱导似乎是裸鼠宿主提供的环境的结果，并且与皮肤移植内的过客淋巴细胞以及移植与宿主之间的同种异体差异无关。我们坚信，这些研究为开发一种实验动物模型系统提供了基础，该系统用于研究表皮细胞Ia表达在增强对皮肤中遇到的抗原的免疫反应中可能发挥的潜在作用。
