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从未经化疗的意大利骨肉瘤患者中建立四种新的人原代细胞培养物。

Establishment of Four New Human Primary Cell Cultures from Chemo-Naïve Italian Osteosarcoma Patients.

作者信息

Laschi Marcella, Bernardini Giulia, Geminiani Michela, Ghezzi Lorenzo, Amato Loredana, Braconi Daniela, Millucci Lia, Frediani Bruno, Spreafico Adriano, Franchi Alessandro, Campanacci Domenico, Capanna Rodolfo, Santucci Annalisa

机构信息

Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Siena, Italy.

Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, Università degli Studi di Siena, Policlinico Le Scotte, Siena, Italy.

出版信息

J Cell Physiol. 2015 Nov;230(11):2718-27. doi: 10.1002/jcp.24996.

DOI:10.1002/jcp.24996
PMID:25809010
Abstract

Osteosarcoma (OS) is a primary highly malignant tumor of bone, affecting predominately adolescents and young adults between 10 and 20 years of age. OS is characterized by an extremely aggressive clinical course, with a rapid development of metastasis to the lung and distant bones.

摘要

骨肉瘤（OS）是一种原发性高度恶性骨肿瘤，主要影响10至20岁的青少年和年轻成年人。骨肉瘤的特点是临床病程极具侵袭性，会迅速转移至肺部和远处骨骼。

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