National Institute for Health and Medical Research (INSERM), UMR-ICAN 1166, Université Pierre et Marie Curie-Paris 6, AP-HP, Pitié-Salpétrière University Hospital, ICAN, Paris, France; Heart Institute-InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil; Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
Biofactors. 2015 Mar-Apr;41(2):67-77. doi: 10.1002/biof.1202. Epub 2015 Mar 23.
Low levels of high-density lipoprotein-cholesterol (HDL-C) constitute an independent biomarker of cardiovascular morbi-mortality. However, recent advances have drastically modified the classical and limited view of HDL as a carrier of 'good cholesterol', and have revealed unexpected levels of complexity in the circulating HDL particle pool. HDL particles are indeed highly heterogeneous in structure, intravascular metabolism and biological activity. This review describes recent progress in our understanding of HDL subpopulations and their biological activities, and focuses on relationships between the structural, compositional and functional heterogeneity of HDL particles.
低水平的高密度脂蛋白胆固醇（HDL-C）是心血管病发病率和死亡率的独立生物标志物。然而，最近的研究进展极大地改变了经典的、有限的将 HDL 视为“好胆固醇”载体的观点，并揭示了循环 HDL 颗粒池中出人意料的复杂程度。HDL 颗粒在结构、血管内代谢和生物学活性方面确实具有高度异质性。本文综述了我们对 HDL 亚群及其生物学活性的理解的最新进展，并重点介绍了 HDL 颗粒的结构、组成和功能异质性之间的关系。
