Spinedi Matteo, Clark Christopher, Zullo Leonardo, Kerksiek Anja, Pistis Giorgio, Castelao Enrique, von Gunten Armin, Preisig Martin, Lütjohann Dieter, Popp Julius
University Hospital of Psychiatry and University of Zürich, Zürich, Switzerland.
Service of Old Age Psychiatry, Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.
iScience. 2024 Jan 24;27(2):109013. doi: 10.1016/j.isci.2024.109013. eCollection 2024 Feb 16.
Neurodegenerative, vascular, and dementia diseases are linked to dysregulations in cholesterol metabolism. Dietary plant sterols, or phytosterols, may interfere to neurodegeneration and cognitive decline, and have cholesterol-lowering, anti-inflammatory, and antioxidant qualities. Here, we investigated the potential associations between circulating cholesterol precursors and metabolites, triglycerides, and phytosterols with cognitive decline in older people by performing multivariate analysis on 246 participants engaged in a population-based prospective study. In our analysis we considered the potential effect of sex and APOEe4. We reveal particular dysregulations of diet-derived phytosterols and endogenous cholesterol synthesis and metabolism, and their variations over time linked to cognitive decline in the general population. These results are significant to the development of interventions to avoid cognitive decline in older adults and suggest that levels of circulating sterols should be taken into account when evaluating risk.
神经退行性疾病、血管疾病和痴呆症与胆固醇代谢失调有关。膳食植物甾醇，即植物固醇，可能会干预神经退行性变和认知能力下降，并且具有降低胆固醇、抗炎和抗氧化的特性。在此，我们通过对参与一项基于人群的前瞻性研究的246名参与者进行多变量分析，调查了循环胆固醇前体、代谢物、甘油三酯和植物甾醇与老年人认知能力下降之间的潜在关联。在我们的分析中，我们考虑了性别和APOEe4的潜在影响。我们发现了饮食来源的植物甾醇以及内源性胆固醇合成和代谢的特定失调，以及它们随时间的变化与普通人群认知能力下降之间的联系。这些结果对于开发预防老年人认知能力下降的干预措施具有重要意义，并表明在评估风险时应考虑循环甾醇水平。
