用环磷酰胺使恢复期Lewis大鼠再次诱发实验性变应性脑脊髓炎

Reinduction of experimental allergic encephalomyelitis in convalescent Lewis rats with cyclophosphamide.

作者信息

Miyazaki C, Nakamura T, Kaneko K, Mori R, Shibasaki H

出版信息

J Neurol Sci. 1985 Mar;67(3):277-84. doi: 10.1016/0022-510x(85)90152-2.

Abstract

Experimental allergic encephalomyelitis (EAE) in Lewis rats is an acute, monophasic autoimmune disease, and rats recovering from EAE are generally resistant to active reinduction. However, following immunosuppression with a high dose (100-200 mg/kg) of cyclophosphamide (CY), EAE was reinduced in convalescent rats, irrespective of whether or not they were rechallenged with the encephalitogenic inoculum. Reinduction of EAE was not observed in rats treated with low doses (20 mg/kg or less) of CY. A selective inhibition of suppressor cells during the convalescent stage may be responsible for the reinduction of EAE in Lewis rats.

摘要

实验性变态反应性脑脊髓炎（EAE）在Lewis大鼠中是一种急性单相自身免疫性疾病，从EAE恢复的大鼠通常对再次主动诱导具有抗性。然而，在用高剂量（100 - 200 mg/kg）环磷酰胺（CY）进行免疫抑制后，恢复期大鼠的EAE被再次诱导，无论它们是否用致脑炎接种物再次攻击。在用低剂量（20 mg/kg或更低）CY处理的大鼠中未观察到EAE的再次诱导。恢复期选择性抑制抑制性细胞可能是Lewis大鼠中EAE再次诱导的原因。