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miR-494在鼻咽癌发生中的功能解析

Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma.

作者信息

Duan Hong-Fang, Li Xiao-Qing, Hu Hong-Yi, Li Yu-Chi, Cai Zhi, Mei Xue-Shuang, Yu Peng, Nie Li-Ping, Zhang Wei, Yu Zhen-Dong, Nie Guo-Hui

机构信息

Department of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.

Guangzhou Medical University, 510000, Guangzhou, Guangdong Province, China.

出版信息

Tumour Biol. 2015 Sep;36(9):6679-89. doi: 10.1007/s13277-015-3356-8. Epub 2015 Mar 26.

DOI:10.1007/s13277-015-3356-8
PMID:25809707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4644213/
Abstract

Nasopharyngeal carcinoma has very high incidence and high mortality worldwide. MiRNA is related to the tumorigenesis and metastasis of a variety of tumors. In the present study, we verify that the expression of miR-494 in NPC tissues and NPC-derived cells was down-regulated, respectively. The proliferation, colony formation, migration, and invasion of NPC-derived cells were suppressed, while the cell apoptosis was promoted, when miR-494 was over-expressed in these cells. GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC.

摘要

鼻咽癌在全球范围内具有很高的发病率和死亡率。微小RNA（miRNA）与多种肿瘤的发生和转移有关。在本研究中，我们证实miR-494在鼻咽癌组织和鼻咽癌衍生细胞中的表达分别下调。当miR-494在这些细胞中过表达时，鼻咽癌衍生细胞的增殖、集落形成、迁移和侵袭受到抑制，而细胞凋亡则被促进。GALNT7和CDK16被证实是miR-494的直接靶点。这些结果表明，miR-494在鼻咽癌的发生中起抑制作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5612/4644213/e93146d9a231/13277_2015_3356_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5612/4644213/103008f07640/13277_2015_3356_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5612/4644213/075197c1d460/13277_2015_3356_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5612/4644213/252462507d96/13277_2015_3356_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5612/4644213/b6f82b7b99be/13277_2015_3356_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5612/4644213/78f945437c0f/13277_2015_3356_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5612/4644213/68674913bf77/13277_2015_3356_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5612/4644213/e93146d9a231/13277_2015_3356_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5612/4644213/103008f07640/13277_2015_3356_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5612/4644213/075197c1d460/13277_2015_3356_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5612/4644213/252462507d96/13277_2015_3356_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5612/4644213/b6f82b7b99be/13277_2015_3356_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5612/4644213/78f945437c0f/13277_2015_3356_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5612/4644213/68674913bf77/13277_2015_3356_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5612/4644213/e93146d9a231/13277_2015_3356_Fig7_HTML.jpg

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