Biomedical Chemistry Institute, Department of Chemistry, New York University, New York, New York 10003, United States.
Biochemistry. 2020 Sep 1;59(34):3098-3110. doi: 10.1021/acs.biochem.9b00784. Epub 2019 Oct 21.
Glycosylation is a sophisticated informational system that controls specific biological functions at the cellular and organismal level. Dysregulation of glycosylation may underlie some of the most complex and common diseases of the modern era. In the past 5 years, microRNAs have come to the forefront as a critical regulator of the glycome. Herein, we review the current literature on miRNA regulation of glycosylation and how this work may point to a new way to identify the biological importance of glycosylation enzymes.
糖基化是一种复杂的信息系统，可控制细胞和机体水平的特定生物学功能。糖基化的失调可能是现代一些最复杂和最常见疾病的基础。在过去的 5 年中，miRNA 作为糖组的关键调节剂而崭露头角。在此，我们综述了 miRNA 对糖基化调控的最新文献，以及这些工作如何为确定糖基化酶的生物学重要性指明新的方向。
