Zhou Cuiping, Duan Xiaohui, Lan Bowen, Liao Junjie, Shen Jun
Department of Radiology, Huizhou Central Municipal Hospital, No.41 Eling Rood North, Huizhou, 516001, Guangdong, China.
Eur Radiol. 2015 Oct;25(10):3035-42. doi: 10.1007/s00330-015-3708-1. Epub 2015 Mar 26.
To determine the prognostic CT and MR imaging features of extranodal non-Hodgkin lymphoma in the head and neck region.
The clinical data and CT and MR imaging features of 59 patients with histologically confirmed extranodal non-Hodgkin lymphoma in the head and neck region were retrospectively reviewed. Subjects included 27 male and 32 female patients between 13 and 81 years of age, with a mean age of 60.3 years. The clinical outcomes were categorized according to whether relapse or metastasis occurred within 2 years after therapy. The association between the clinical outcome and radiologic factors including tumour size, margin, shape, local tumour invasiveness, regional lymph node involvement, number of involvement sites, and contrast enhancement patterns was determined using univariate and multiple logistic regression analysis.
Radiologic factors including tumour size, margin, shape, and local tumour invasiveness were associated with poor clinical outcomes, as determined by univariate analysis (P < 0.05). Only the lesion margin category (ill-defined) remained an independent risk factor for clinical outcome in multivariate logistic regression analysis, with an OR of 8.14 (P < 0.05).
Ill-defined margin of the primary lesion was indicative of unfavourable survival outcome for patients with extranodal non-Hodgkin lymphoma of the head and neck region.
• Tumour size, margin, shape and local tumour invasiveness were prognostically relevant. • Tumour margin was an independent risk factor for clinical outcome. • Ill-defined margin of primary lesion was indicative of unfavourable survival outcome.
确定头颈部结外非霍奇金淋巴瘤的预后CT和MR成像特征。
回顾性分析59例经组织学证实的头颈部结外非霍奇金淋巴瘤患者的临床资料以及CT和MR成像特征。研究对象包括27例男性和32例女性患者，年龄在13至81岁之间，平均年龄为60.3岁。根据治疗后2年内是否发生复发或转移对临床结局进行分类。采用单因素和多因素逻辑回归分析确定临床结局与包括肿瘤大小、边缘、形状、局部肿瘤侵袭性、区域淋巴结受累情况、受累部位数量以及对比增强模式等放射学因素之间的关联。
单因素分析显示，包括肿瘤大小、边缘、形状和局部肿瘤侵袭性在内的放射学因素与不良临床结局相关（P < 0.05）。在多因素逻辑回归分析中，仅病变边缘类别（边界不清）仍是临床结局的独立危险因素，比值比为8.14（P < 0.05）。
头颈部结外非霍奇金淋巴瘤患者原发灶边缘不清提示生存结局不佳。
• 肿瘤大小、边缘、形状和局部肿瘤侵袭性与预后相关。• 肿瘤边缘是临床结局的独立危险因素。• 原发灶边缘不清提示生存结局不佳。
