India Diabetes Research Foundation, Chennai, 600008, Tamil Nadu, India.
Dr. A. Ramachandran's Diabetes Hospitals, Chennai, 600008, Tamil Nadu, India.
Biofactors. 2015 May 6;41(3):160-5. doi: 10.1002/biof.1209. Epub 2015 Mar 23.
The association of retinol binding protein-4 (RBP4) with incident type 2 diabetes (T2DM) in Asian Indian middle-aged men with impaired glucose tolerance (IGT) was studied. This was an ancillary analysis of a subsample from a cohort of participants with IGT in a 2 year prospective diabetes prevention program in India. For this analysis, 71 incident T2DM and 76 non-diabetic cases (non-progressors) based on the final glycemic outcome were selected. Baseline serum RBP4 was measured using competitive enzyme immunoassay. Correlations of RBP4 with relevant anthropometric and biochemical variables and also its association with diabetes were assessed using appropriate statistical analyses. Participants who developed T2DM had higher levels of serum RBP4 (21.3 [IQR: 17.7-24.9] µg/mL) compared with non-progressors (17.3 [IQR: 13.1-21.0] µg/mL; P = 0.001). Levels of RBP4 were lower than in Caucasians. Stepwise linear regression analysis showed that body mass index (BMI), systolic blood pressure, triglycerides, and HbA1c had independent associations with RBP4 levels. Multiple logistic regression analyses showed that RBP4 was independently associated with incident diabetes (odds ratio [OR] [95%confidence interval (CI)]: 1.69 [1.18-2.41]; P = 0.004). Adjustment for study group, age, BMI, waist circumference, 2 H plasma glucose, triglycerides, gamma glutamyl transferase, and insulin resistance weakened the significance of its association (OR [95%CI]: 1.65 [1.03-2.66]; P = 0.038).The results of this preliminary analyses showed that baseline serum RBP4 levels were independently associated with incident diabetes in Asian Indian men with IGT. It may be used as an additional predictor of future diabetes.
本研究旨在探讨血清视黄醇结合蛋白 4（RBP4）与印度裔中年糖耐量受损（IGT）人群中 2 型糖尿病（T2DM）发病风险的相关性。该研究为印度一项为期 2 年的糖尿病预防计划中 IGT 队列亚组的辅助分析。本分析共纳入 71 例新发 T2DM 患者和 76 例血糖控制未进展的非糖尿病患者（非进展组）。采用竞争酶联免疫吸附法检测基线血清 RBP4 水平。采用适当的统计学方法评估 RBP4 与相关人体测量学和生化变量的相关性及其与糖尿病的相关性。与非进展组相比，发生 T2DM 的患者血清 RBP4 水平更高[21.3（IQR：17.7-24.9）µg/ml]（P=0.001）。与白人相比，RBP4 水平较低。逐步线性回归分析显示，体重指数（BMI）、收缩压、甘油三酯和糖化血红蛋白（HbA1c）与 RBP4 水平独立相关。多因素 logistic 回归分析显示，RBP4 与新发糖尿病独立相关（比值比[OR] [95%置信区间（CI）]：1.69 [1.18-2.41]；P=0.004）。调整研究组、年龄、BMI、腰围、2 小时血糖、甘油三酯、γ-谷氨酰转移酶和胰岛素抵抗后，其相关性的显著性减弱（OR [95%CI]：1.65 [1.03-2.66]；P=0.038）。本初步分析结果表明，基线血清 RBP4 水平与印度裔中年 IGT 人群的新发糖尿病独立相关。RBP4 可能作为未来糖尿病的一个附加预测指标。
