Si Yueqiao, Liu Jingyi, Han Chao, Wang Ruijuan, Liu Tong, Sun Lixian
Department of Cardiology, The Affiliated Hospital of Chengde Medical University, Chengde, 067000, Hebei, China.
Heart Vessels. 2020 Nov;35(11):1494-1501. doi: 10.1007/s00380-020-01627-8. Epub 2020 May 24.
Retinol-binding protein-4 (RBP-4) along with the lipid profile plays crucial roles in Acute coronary syndrome (ACS). The study aimed to investigate the correlation of RBP-4, lipoprotein combine index (LCI), and RBP-4 + LCI with ACS. 163 ACS and 77 non-CAD in patients were consecutively enrolled in this study. The serum level of RBP-4 was measured via enzyme-linked immunosorbent assay. LCI was calculated using the formula: total cholesterol × triglyceride × low-density lipoprotein cholesterol/high-density lipoprotein cholesterol. RBP-4 ≥4 ng/ml, LCI ≥16 and LCI ≥16 + RBP-4 ≥4 ng/ml were new independent risk factors of ACS, and OR value of LCI ≥16 + RBP-4 ≥4 ng/ml was higher than that of RBP-4 and LCI combined (all p < 0.05). The AUC for LCI + RBP-4 was higher than that for LCI and RBP-4 individually. The risk of high LCI in 1 lesion vessel was greater than those of 2 or ≥3 lesion vessels (all p < 0.05). In 1 lesion vessel or ≥3 lesion vessels group, the risk associated with LCI and RBP-4 combined was higher than the risk of LCI or RBP-4 alone (all p < 0.05). The risk of hypertension, diabetes mellitus, smoking and history of MI increased with numbers of vessels lesion (all p < 0.05). Increase in RBP-4 and LCI values were found to be independent risk factors for ACS, and the risk of the combined rise in LCI and RBP-4 values was higher than LCI or RBP-4 alone. The combined tests of LCI and RBP-4 might be a potential diagnostic marker for ACS.
视黄醇结合蛋白4（RBP - 4）与血脂谱在急性冠状动脉综合征（ACS）中起关键作用。本研究旨在探讨RBP - 4、脂蛋白综合指数（LCI）以及RBP - 4 + LCI与ACS的相关性。本研究连续纳入了163例ACS患者和77例非冠心病患者。通过酶联免疫吸附测定法检测血清RBP - 4水平。LCI采用以下公式计算：总胆固醇×甘油三酯×低密度脂蛋白胆固醇/高密度脂蛋白胆固醇。RBP - 4≥4 ng/ml、LCI≥16以及LCI≥16 + RBP - 4≥4 ng/ml是ACS新的独立危险因素，且LCI≥16 + RBP - 4≥4 ng/ml的OR值高于RBP - 4和LCI单独作用时（所有p < 0.05）。LCI + RBP - 4的曲线下面积（AUC）高于LCI和RBP - 4单独的AUC。单支病变血管中高LCI的风险大于双支或≥三支病变血管（所有p < 0.05）。在单支病变血管或≥三支病变血管组中，LCI和RBP - 4联合作用的风险高于LCI或RBP - 4单独作用时（所有p < 0.05）。高血压、糖尿病、吸烟和心肌梗死病史的风险随病变血管数量增加而升高（所有p < 0.05）。发现RBP - 4和LCI值升高是ACS的独立危险因素，且LCI和RBP - 4值联合升高的风险高于LCI或RBP - 4单独升高时。LCI和RBP - 4联合检测可能是ACS的一种潜在诊断标志物。
