选择性雌激素受体调节剂用于卵巢保护的挑战与潜力
Challenges and Potential for Ovarian Preservation with SERMs.
作者信息
Ting Alison Y, Petroff Brian K
机构信息
Division of Reproduction and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon.
Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan
出版信息
Biol Reprod. 2015 May;92(5):133. doi: 10.1095/biolreprod.115.128207. Epub 2015 Mar 25.
Abstract
Tamoxifen (TAM) is a selective estrogen receptor modulator with tissue-specific effects on estrogen signaling used predominantly for treatment and chemoprevention of breast cancers. Recent studies have shown that TAM prevents infertility and decreases follicular loss from common cancer chemotherapy and radiation therapy in preclinical models. Here we review current and novel uses of selective estrogen receptor modulator s and advantages and challenges for translation of TAM for human fertility preservation.
摘要
他莫昔芬（TAM）是一种选择性雌激素受体调节剂，对雌激素信号传导具有组织特异性作用，主要用于乳腺癌的治疗和化学预防。最近的研究表明，在临床前模型中，他莫昔芬可预防不孕症，并减少常见癌症化疗和放疗引起的卵泡损失。在此，我们综述选择性雌激素受体调节剂的当前和新用途，以及他莫昔芬在人类生育力保存应用方面的优势和挑战。
相似文献
1
Challenges and Potential for Ovarian Preservation with SERMs.选择性雌激素受体调节剂用于卵巢保护的挑战与潜力
Biol Reprod. 2015 May;92(5):133. doi: 10.1095/biolreprod.115.128207. Epub 2015 Mar 25.
2
Tamoxifen prevents apoptosis and follicle loss from cyclophosphamide in cultured rat ovaries.他莫昔芬可预防环磷酰胺诱导的培养大鼠卵巢细胞凋亡和卵泡丢失。
Biol Reprod. 2015 May;92(5):132. doi: 10.1095/biolreprod.114.126136. Epub 2015 Apr 1.
3
Selective estrogen receptor modulators inhibit growth and progression of premalignant lesions in a mouse model of ductal carcinoma in situ.选择性雌激素受体调节剂可抑制原位导管癌小鼠模型中癌前病变的生长和进展。
Breast Cancer Res. 2005;7(6):R881-9. doi: 10.1186/bcr1317. Epub 2005 Sep 13.
4
Insights into the protective mechanisms of tamoxifen in radiotherapy-induced ovarian follicular loss: impact on insulin-like growth factor 1.探讨他莫昔芬在放射治疗诱导的卵巢卵泡耗竭中的保护机制：对胰岛素样生长因子 1 的影响。
Endocrinology. 2013 Oct;154(10):3888-99. doi: 10.1210/en.2013-1214. Epub 2013 Jun 24.
5
[Selective estrogen receptor modulators (SERMs) in the practice].[实践中的选择性雌激素受体调节剂（SERMs）]
Magy Onkol. 2002;46(2):165-75. Epub 2002 Aug 29.
6
Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway.选择性雌激素受体调节剂通过雌激素受体依赖途径抑制小胶质细胞活化和神经元细胞死亡。
J Steroid Biochem Mol Biol. 2015 Jan;145:85-93. doi: 10.1016/j.jsbmb.2014.10.002. Epub 2014 Oct 8.
7
Tamoxifen decreases ovarian toxicity without compromising cancer treatment in a rat model of mammary cancer.他莫昔芬可降低卵巢毒性，同时不影响乳腺癌大鼠模型中的癌症治疗。
BMC Genomics. 2023 Jun 13;24(1):325. doi: 10.1186/s12864-023-09423-0.
8
5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of tamoxifen in breast cancer cells.5,6-环氧胆固醇有助于他莫昔芬在乳腺癌细胞中的抗癌药理学作用。
Biochem Pharmacol. 2013 Jul 1;86(1):175-89. doi: 10.1016/j.bcp.2013.02.031. Epub 2013 Mar 7.
9
Selective estrogen receptor modulators and the combination therapy conjugated estrogens/bazedoxifene: A review of effects on the breast.选择性雌激素受体调节剂及结合雌激素/巴多昔芬联合疗法：对乳腺影响的综述
Post Reprod Health. 2015 Sep;21(3):112-21. doi: 10.1177/2053369115599090. Epub 2015 Aug 19.
10
Tamoxifen prevents premalignant changes of breast, but not ovarian, cancer in rats at high risk for both diseases.他莫昔芬可预防大鼠乳腺癌的癌前病变，但不能预防卵巢癌的癌前病变，这两种疾病在大鼠中均处于高风险状态。
Cancer Prev Res (Phila). 2008 Dec;1(7):546-53. doi: 10.1158/1940-6207.CAPR-08-0015.
引用本文的文献
1
The Role of lncRNAs in the Protective Action of Tamoxifen on the Ovaries of Tumor-Bearing Rats Receiving Cyclophosphamide.长链非编码RNA在他莫昔芬对接受环磷酰胺的荷瘤大鼠卵巢保护作用中的作用
Int J Mol Sci. 2024 Nov 22;25(23):12538. doi: 10.3390/ijms252312538.
2
Molecular Action of Tamoxifen in the Ovaries of Rats with Mammary Neoplasia.他莫昔芬在患有乳腺癌的大鼠卵巢中的分子作用。
Int J Mol Sci. 2023 Oct 30;24(21):15767. doi: 10.3390/ijms242115767.
3
Tamoxifen decreases ovarian toxicity without compromising cancer treatment in a rat model of mammary cancer.他莫昔芬可降低卵巢毒性，同时不影响乳腺癌大鼠模型中的癌症治疗。
BMC Genomics. 2023 Jun 13;24(1):325. doi: 10.1186/s12864-023-09423-0.
4
Impact of tamoxifen therapy on fertility in breast cancer survivors.他莫昔芬治疗对乳腺癌幸存者生育能力的影响。
Fertil Steril. 2017 Jan;107(1):243-252.e5. doi: 10.1016/j.fertnstert.2016.10.020. Epub 2016 Nov 22.
5
LH prevents cisplatin-induced apoptosis in oocytes and preserves female fertility in mouse.促黄体生成素可防止顺铂诱导的卵母细胞凋亡，并维持小鼠的雌性生育能力。
Cell Death Differ. 2017 Jan;24(1):72-82. doi: 10.1038/cdd.2016.97. Epub 2016 Sep 30.
本文引用的文献
1
Tamoxifen prevents apoptosis and follicle loss from cyclophosphamide in cultured rat ovaries.他莫昔芬可预防环磷酰胺诱导的培养大鼠卵巢细胞凋亡和卵泡丢失。
Biol Reprod. 2015 May;92(5):132. doi: 10.1095/biolreprod.114.126136. Epub 2015 Apr 1.
2
Breast cancer: tamoxifen - offering a long-term prevention option.乳腺癌：他莫昔芬——提供一种长期预防选择。
Nat Rev Clin Oncol. 2015 Feb;12(2):66. doi: 10.1038/nrclinonc.2014.236. Epub 2015 Jan 13.
3
Update on breast cancer risk prediction and prevention.乳腺癌风险预测与预防的最新进展。
Curr Opin Obstet Gynecol. 2015 Feb;27(1):92-7. doi: 10.1097/GCO.0000000000000153.
4
Gonadotropin-releasing hormone agonists for the preservation of ovarian function among women with breast cancer who did not use tamoxifen after chemotherapy: a systematic review and meta-analysis.促性腺激素释放激素激动剂在未使用他莫昔芬的化疗后乳腺癌女性中的卵巢功能保护作用：系统评价和荟萃分析。
Fertil Steril. 2014 Sep;102(3):808-815.e1. doi: 10.1016/j.fertnstert.2014.06.003. Epub 2014 Jul 17.
5
Tamoxifen co-administration during controlled ovarian hyperstimulation for in vitro fertilization in breast cancer patients increases the safety of fertility-preservation treatment strategies.在乳腺癌患者体外受精的控制性卵巢刺激过程中联合使用他莫昔芬可提高生育力保留治疗策略的安全性。
Fertil Steril. 2014 Aug;102(2):488-495.e3. doi: 10.1016/j.fertnstert.2014.05.017. Epub 2014 Jun 14.
6
IGF1R signaling is necessary for FSH-induced activation of AKT and differentiation of human Cumulus granulosa cells.胰岛素样生长因子1受体（IGF1R）信号传导对于促卵泡激素（FSH）诱导的蛋白激酶B（AKT）激活和人卵丘颗粒细胞分化是必需的。
J Clin Endocrinol Metab. 2014 Aug;99(8):2995-3004. doi: 10.1210/jc.2014-1139. Epub 2014 May 21.
7
A tamoxifen derivative, N,N-diethyl-2-[4-(phenylmethyl) phenoxy] ethanamine, selectively targets P-glycoprotein-positive multidrug resistant Chinese hamster cells.一种他莫昔芬衍生物，N,N-二乙基-2-[4-(苯甲基)苯氧基]乙胺，选择性靶向 P-糖蛋白阳性多药耐药中国仓鼠细胞。
Biochem Pharmacol. 2014 Jul 15;90(2):107-14. doi: 10.1016/j.bcp.2014.04.017. Epub 2014 May 10.
8
Evaluation of the effect of GnRH agonist on menstrual reverse in breast cancer cases treated with cyclophosphamide.评估促性腺激素释放激素激动剂对接受环磷酰胺治疗的乳腺癌患者月经逆转的影响。
Eur J Gynaecol Oncol. 2014;35(1):59-61.
9
Tamoxifen as an effective neuroprotectant against early brain injury and learning deficits induced by subarachnoid hemorrhage: possible involvement of inflammatory signaling.他莫昔芬作为一种有效的神经保护剂，可预防蛛网膜下腔出血引起的早期脑损伤和学习缺陷：可能涉及炎症信号。
J Neuroinflammation. 2013 Dec 28;10:157. doi: 10.1186/1742-2094-10-157.
10
Gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in cancer women: systematic review and meta-analysis of randomized trials.促性腺激素释放激素类似物预防癌症女性化疗引起的卵巢早衰的系统评价和随机试验荟萃分析。
Cancer Treat Rev. 2014 Jun;40(5):675-83. doi: 10.1016/j.ctrv.2013.12.001. Epub 2013 Dec 8.
Zotero 插件