Cardiovascular Research Center, Modarres Hospital, Cardiovascular Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iranian Research Center for HIV/AIDS (IRCHA), Iranian Institute for Reduction of High-Risk Behaviors, Students' Scientific Research Center (SSRC) , Tehran University of Medical Sciences, Tehran, Iran.
Korean Circ J. 2015 Mar;45(2):158-60. doi: 10.4070/kcj.2015.45.2.158. Epub 2015 Mar 24.
This case report underscores that crystal methamphetamine abuse is an important cause of multivessel coronary thrombosis and raises doubts about the therapeutic options. The patient was a 34-year-old smoker and crystal methamphetamine abuser with no significant medical history, who presented with retrosternal chest pain associated with cold sweats. Twelve-lead electrocardiogram revealed diffuse ST-segment elevation in I, II, AVL, AVF, and V 2-6 leads. He underwent urgent coronary angiography and it showed Thrombolysis in Myocardial Infarction (TIMI) grade 3 flow in coronary arteries and presence of a thrombus in the left anterior descending artery (LAD) and the right coronary artery (RCA). The patient underwent medical therapy with antiplatelet agents and anticoagulants. Repeat coronary angiography after three months of dual therapy with warfarin and aspirin did not show any thrombus or any significant lesion in the RCA and the LAD having TIMI grade 3 flow.
本病例报告强调,吸食冰毒是导致多支冠状动脉血栓形成的一个重要原因,并对治疗选择提出了质疑。患者为 34 岁吸烟者,有冰毒滥用史,无重大病史,表现为胸骨后胸痛,伴有冷汗。十二导联心电图显示 I、II、AVL、AVF 和 V2-6 导联弥漫性 ST 段抬高。他接受了紧急冠状动脉造影,结果显示冠状动脉血流达到心肌梗死溶栓治疗(TIMI)3 级,左前降支(LAD)和右冠状动脉(RCA)存在血栓。患者接受了抗血小板和抗凝药物的药物治疗。华法林和阿司匹林双联治疗 3 个月后再次进行冠状动脉造影,结果显示 RCA 和 LAD 未见血栓或任何明显病变,血流达到 TIMI 3 级。