Jamaldeen Jishana, Basheer Aneesh, Sarma Akhil Chandra, Kandasamy Ravichandran
Department of Otorhinolaryngology, Pondicherry Institute of Medical Sciences, Pondicherry, India.
Department of General Medicine, Pondicherry Institute of Medical Sciences, Pondicherry, India.
Australas Med J. 2015 Feb 28;8(2):41-6. doi: 10.4066/AMJ.2015.2258. eCollection 2015.
The prevalence, degree, and patterns of hearing loss associated with chronic kidney disease (CKD) reported by various studies differ significantly. The effects of haemodialysis and duration of disease on hearing loss remain unclear.
The aim of this study was to determine the prevalence and degree of hearing loss in CKD patients on haemodialysis.
This study included 120 CKD patients on haemodialysis. Information regarding age, gender, duration of disease, subjective hearing loss, exposure to ototoxic drugs, comorbidities like diabetes, hypertension, and hypothyroidism, renal functions, electrolytes and number of haemodialysis sessions received were obtained. An equal number of age and sex matched controls were used to determine prevalence of hearing loss in CKD patients after subjecting both groups to pure tone audiometry. We compared CKD patients with and without hearing loss for association of hearing loss with disease duration, number of haemodialysis, and blood parameters.
Hearing loss was present in 41.7 per cent of CKD patients, significantly higher than controls (p=0.001), and was mild in the majority of patients. Impairment was noted across high and low frequencies of audiometric testing. Median duration of disease was the same (18 months) among CKD patients with and without hearing loss (p=0.62). CKD patients with hearing loss received 72 haemodialysis compared to 122 sessions by those without hearing loss (p=0.04).
Mild sensorineural hearing loss is common in CKD. Hearing loss has no specific pattern as it prevails at high and low frequencies. Hearing loss may be inversely associated with the number of haemodialysis sessions but not with duration of disease.
各项研究报告的与慢性肾脏病（CKD）相关的听力损失患病率、程度和模式差异显著。血液透析及疾病持续时间对听力损失的影响仍不明确。
本研究旨在确定接受血液透析的CKD患者的听力损失患病率及程度。
本研究纳入120例接受血液透析的CKD患者。获取了有关年龄、性别、疾病持续时间、主观听力损失、耳毒性药物暴露、糖尿病、高血压和甲状腺功能减退等合并症、肾功能、电解质以及接受血液透析次数的信息。在两组均接受纯音听力测定后，使用数量相等的年龄和性别匹配的对照来确定CKD患者的听力损失患病率。我们比较了有和无听力损失的CKD患者，以探讨听力损失与疾病持续时间、血液透析次数和血液参数之间的关联。
41.7%的CKD患者存在听力损失，显著高于对照组（p = 0.001），且大多数患者为轻度听力损失。在听力测试的高频和低频均发现了损伤。有和无听力损失的CKD患者的疾病中位持续时间相同（18个月）（p = 0.62）。有听力损失的CKD患者接受了72次血液透析，而无听力损失的患者接受了122次（p = 0.04）。
轻度感音神经性听力损失在CKD中很常见。听力损失无特定模式，在高频和低频均有发生。听力损失可能与血液透析次数呈负相关，但与疾病持续时间无关。
