Akcakaya Mehmet Osman, Bilgic Bilge, Aras Yavuz, Izgi Nail
Department of Neurosurgery, School of Medicine, Istanbul University, Istanbul, Turkey.
Department of Pathology, School of Medicine, Istanbul University, Istanbul, Turkey.
J Korean Neurosurg Soc. 2015 Mar;57(3):211-4. doi: 10.3340/jkns.2015.57.3.211. Epub 2015 Mar 20.
Ganglioneuromas are benign tumors. Surgical excision is the treatment of choice with very good prognosis. However, neuroblastomatous malignant transformation of ganglioneuromas was previously reported. We report a patient with spinal neuroblastoma recurrent from a ganglioneuroblastoma after disease free survival of 13 years. This is one of the rare examples of spinal neuroblastoma and to our knowledge the second case report with malignant transformation from a ganglioneuroblastoma or a ganglioneuroma. The present case is the only report in the literature with further genetic investigations.
神经节神经瘤是良性肿瘤。手术切除是首选治疗方法，预后良好。然而，此前有神经节神经瘤发生神经母细胞瘤恶性转化的报道。我们报告了一例患者，其脊髓神经母细胞瘤由节细胞神经母细胞瘤复发而来，已无病生存13年。这是脊髓神经母细胞瘤的罕见病例之一，据我们所知，这是第二例节细胞神经母细胞瘤或神经节神经瘤发生恶性转化的病例报告。本病例是文献中唯一进行了进一步基因研究的报告。
