Kim Sangmi, Rimando Joseph, Sandler Dale P
a Department of Medicine, Section of Hematology/Oncology, Medical College of Georgia, Georgia Regents University Cancer Center , Augusta , Georgia , USA.
Nutr Cancer. 2015;67(4):580-6. doi: 10.1080/01635581.2015.1011787. Epub 2015 Mar 26.
Prostaglandin E2 (PGE2) is an inflammatory mediator that plays key roles in promoting tumor development and progression. Urinary concentration of a major PGE2 metabolite (PGE-M) has been recently proposed as a promising cancer biomarker. Using dietary intake data from 600 postmenopausal women aged 50-74 years, we examined cross-sectional relationships between fruit and vegetable intake and urinary levels of PGE-M, determined using liquid chromatography/tandem mass spectrometry. After multivariable adjustment, increasing consumption of fruits, but not vegetables, was associated with reduced levels of urinary PGE-M (P for linear trend = 0.02), with geometric means of 5.8 [95% confidence interval (CI): 5.2-6.6] in the lowest quintile versus 4.8 (95% CI: 4.3-5.4) in the highest quintile (Q5) of fruit consumption. A better quality diet, indicated by higher scores on the Healthy Eating Index, was also associated with decreased PGE-M (P for linear trend <0.01). The lack of association with vegetable intake may be related to variation in antioxidant capacities of the major dietary sources of fruits and vegetables for the study participants. Our findings suggest that urinary PGE-M may be modifiable by a healthy diet that follows current national dietary guideline. Further studies are warranted to assess potential utility of urinary PGE-M in assessing cancer prevention efficacy.
前列腺素E2(PGE2)是一种炎症介质,在促进肿瘤发展和进展中起关键作用。最近有人提出,主要PGE2代谢物(PGE-M)的尿浓度有望成为一种癌症生物标志物。我们利用600名年龄在50-74岁之间的绝经后女性的饮食摄入数据,研究了水果和蔬菜摄入量与通过液相色谱/串联质谱法测定的尿PGE-M水平之间的横断面关系。经过多变量调整后,水果摄入量的增加而非蔬菜摄入量的增加与尿PGE-M水平的降低有关(线性趋势P = 0.02),水果摄入量最低五分位数组的几何均值为5.8 [95%置信区间(CI):5.2-6.6],而最高五分位数组(Q5)为4.8(95% CI:4.3-5.4)。健康饮食指数得分较高表明饮食质量较好,这也与PGE-M水平降低有关(线性趋势P <)。与蔬菜摄入量缺乏关联可能与研究参与者水果和蔬菜的主要饮食来源的抗氧化能力差异有关。我们的研究结果表明,遵循当前国家饮食指南的健康饮食可能会改变尿PGE-M水平。有必要进一步研究评估尿PGE-M在评估癌症预防效果方面的潜在效用。