Abdel-Rehim Asmaa S M, Sheha Dina S, Mohamed Nesrine A
Egypt J Immunol. 2014;21(2):85-90.
Vitamin D has an important role in the immune system. Decreased serum vitamin D level is known to be associated with autoimmune and atopic diseases. This study aimed to assess vitamin D status in patients with chronic spontaneous urticaria (CSU) and its relation with severity of the disease. This case-control study was conducted on 22 patients and 20 age and sex matched controls. Patients were subjected to clinical assessment, routine laboratory examination: complete blood picture (CBC), erythrocyte sedimentation rate (ESR), hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV Ab), anti-thyroid antibody, anti-nuclear antibody (ANA), total immunoglobulin E (IgE), vitamin D assay and stool analysis, and special investigations including: skin prick test (SPT), autologous serum skin test (ASST) and urticaria activity score (UAS). Patients' mean age was 32.8 ± 13.17 years. The median and interquartile range of duration of illness was 2.5 (1-4) years and of Ig E was 79 (62-312) IU/ml. According to UAS; 14 (63.6%) had severe and 8 (36.4%) had moderate degree illness. The mean vitamin D level among the patients was 28.4 ± 9.09 nmol/L. Vitamin D level was significantly lower among patients in comparison to controls (28.4 ± 9.09 vs. 104.5 ± 76.8, t = 4.4 P < 0.01). Vitamin D correlated negatively with IgE level (r = -0.45, P < 0.05), meanwhile it was insignificantly correlated with age and duration of illness (r = -0.117 and 0.34 respectively, P > 0.05). In conclusion; Low vitamin D level (r = 0.45) is associated with chronic spontaneous urticaria but has no relation with the severity of the disease.
维生素D在免疫系统中发挥着重要作用。血清维生素D水平降低已知与自身免疫性疾病和特应性疾病有关。本研究旨在评估慢性自发性荨麻疹（CSU）患者的维生素D状况及其与疾病严重程度的关系。本病例对照研究对22例患者和20例年龄及性别匹配的对照者进行。对患者进行临床评估、常规实验室检查：全血细胞计数（CBC）、红细胞沉降率（ESR）、乙肝表面抗原（HBsAg）、丙肝病毒抗体（HCV Ab）、抗甲状腺抗体、抗核抗体（ANA）、总免疫球蛋白E（IgE）、维生素D检测和粪便分析，以及特殊检查，包括：皮肤点刺试验（SPT）、自体血清皮肤试验（ASST）和荨麻疹活动评分（UAS）。患者的平均年龄为32.8±13.17岁。病程的中位数和四分位间距为2.5（1 - 4）年，Ig E的中位数和四分位间距为79（62 - 312）IU/ml。根据UAS；14例（63.6%）病情严重，8例（36.4%）病情中度。患者的平均维生素D水平为28.4±9.09 nmol/L。与对照组相比，患者的维生素D水平显著降低（28.4±9.09 vs. 104.5±76.8，t = 4.4，P < 0.01）。维生素D与IgE水平呈负相关（r = -0.45，P < 0.05），同时与年龄和病程无显著相关性（分别为r = -0.117和0.34，P > 0.05）。总之；低维生素D水平（r = 0.45）与慢性自发性荨麻疹有关，但与疾病严重程度无关。
