Baek Y S, Jeon J, Kim J H, Oh C H
Department of Dermatology, College of Medicine, Korea University, Seoul, Korea.
Clin Exp Dermatol. 2014 Oct;39(7):795-800. doi: 10.1111/ced.12413. Epub 2014 Sep 5.
Although various scoring systems for measuring urticaria severity have been introduced, most rely on subjective criteria. Therefore, additional objective criteria such as laboratory markers would be helpful adjuncts in making this assessment.
To evaluate the usefulness of three laboratory markers [D-dimer, C-reactive protein (CRP), and total IgE] in assessing disease severity of both acute urticaria (AU) and chronic urticaria (CU).
We conducted a retrospective analysis of 94 patients with urticaria. Correlations between the aforementioned laboratory markers and the Urticaria Activity Score (UAS) were calculated.
A substantial proportion of patients with urticaria (acute 43.5%; chronic 39.6%) had an increased D-dimer level. Additionally, there was a significant correlation between D-dimer level and UAS (AU r = 0.60, P < 0.001; CU r = 0.37, P < 0.05). However, there was no significant correlation between UAS and either CRP or total IgE.
D-dimer level could be used as a marker of disease severity for both AU and CU. However, CRP and total IgE are not as reliable in predicting disease severity.
尽管已经引入了各种用于衡量荨麻疹严重程度的评分系统，但大多数都依赖主观标准。因此，诸如实验室指标等额外的客观标准将有助于进行这一评估。
评估三种实验室指标[D-二聚体、C反应蛋白（CRP）和总IgE]在评估急性荨麻疹（AU）和慢性荨麻疹（CU）疾病严重程度方面的有用性。
我们对94例荨麻疹患者进行了回顾性分析。计算上述实验室指标与荨麻疹活动评分（UAS）之间的相关性。
相当一部分荨麻疹患者（急性患者中占43.5%；慢性患者中占39.6%）的D-二聚体水平升高。此外，D-二聚体水平与UAS之间存在显著相关性（AU中r = 0.60，P < 0.001；CU中r = 0.37，P < 0.05）。然而，UAS与CRP或总IgE之间均无显著相关性。
D-二聚体水平可作为AU和CU疾病严重程度的指标。然而，CRP和总IgE在预测疾病严重程度方面不太可靠。
