T淋巴细胞在患有先兆子痫的妊娠合并病因不明绒毛膜羊膜炎的胎盘组织中的作用。
Involvement of T lymphocytes in the placentae with villitis of unknown etiology from pregnancies complicated with preeclampsia.
作者信息
Benzon Sandra, Zekić Tomaš Sandra, Benzon Zdeslav, Vulić Marko, Kuzmić Prusac Ivana
机构信息
a Department of Gynecology and Obstetrics , University Hospital Split, School of Medicine, University of Split , Split , Croatia .
b School of Medicine, University of Split , Split , Croatia , and.
出版信息
J Matern Fetal Neonatal Med. 2016;29(7):1055-60. doi: 10.3109/14767058.2015.1032239. Epub 2015 Apr 9.
OBJECTIVE
The aim of the study was to compare immunohistochemical expression of different T type lymphocytes in foci of villitis of placentae with villitis of unknown etiology (VUE) without and with preeclampsia (PE).
METHODS
Fifty-four placentae were collected from women who had VUE with (N = 27) and without (N = 27) PE. Immunohistochemistry for types of T lymphocytes was performed on formalin fixed and paraffin-embedded sections by use of the CD3, CD4, FOXP3, CD25, CD8 and CD68 antibodies. All data analyses were done by R Development Core Team.
RESULTS
There was higher immunohistochemical CD4 positive T lymphocyte count and CD4 positive/CD8 positive ratio in placentae with VUE complicated with PE compared to control group.
CONCLUSION
The higher immunohistochemical CD4 positive T lymphocyte count and CD4 positive/CD8 positive ratio in placentae with VUE complicated with PE could point to their role in ethiopathogenesis of PE.
目的
本研究旨在比较不明原因绒毛膜羊膜炎（VUE）伴和不伴子痫前期（PE）的胎盘绒毛炎病灶中不同T型淋巴细胞的免疫组化表达情况。
方法
收集54例患有VUE伴（N = 27）和不伴（N = 27）PE的孕妇的胎盘。使用CD3、CD4、FOXP3、CD25、CD8和CD68抗体，对福尔马林固定、石蜡包埋切片进行T淋巴细胞类型的免疫组化检测。所有数据分析均由R开发核心团队完成。
结果
与对照组相比，VUE合并PE的胎盘免疫组化CD4阳性T淋巴细胞计数及CD4阳性/CD8阳性比值更高。
结论
VUE合并PE的胎盘中免疫组化CD4阳性T淋巴细胞计数及CD4阳性/CD8阳性比值更高，这可能表明它们在PE的病因发病机制中起作用。
Zotero 插件