Villitis in normal term human placentae: frequency of the lesion determined by monoclonal antibody to HLA-DR antigen.

Chronic villitis is a placental lesion of unestablished etiology. It is characterized by destruction of chorionic villi with a mononuclear infiltrate and focal areas of fibrinoid necrosis. The lesion frequently is seen in normal placentae, yet more lesions have been reported in placentae from abnormal pregnancies. We measured the extent of villitis in 25 normal term placentae by using both light microscopy and immunocytology for class II (HLA-DR) antigens of the major histocompatibility complex. HLA-DR antigens were found to be characteristic of villitis areas. Normal placentae showed striking variations in the incidence of villitis, but these variations did not correlate with clinical outcome.