Freed W J
Pharmacol Biochem Behav. 1985 Apr;22(4):641-3. doi: 10.1016/0091-3057(85)90288-6.
Betaine (N,N,N-trimethylglycine) and N,N-dimethylglycine have been reported to have anticonvulsant properties in animals. The purpose of the present study was to determine whether these compounds can antagonize strychnine-induced seizures when administered intraperitoneally and to compare their effects with those of sarcosine (N-methylglycine) and glycine. Betaine, N,N-dimethylglycine and sarcosine were equipotent in decreasing the incidence of seizures and death, causing a 38 to 72 percent decrease in the incidence of seizures and death at a dosage of 5 mmole/kg. Glycine had no effect. Thus anticonvulsant activity is conferred to glycine by a single N-methylation.
据报道，甜菜碱（N，N，N-三甲基甘氨酸）和N，N-二甲基甘氨酸在动物体内具有抗惊厥特性。本研究的目的是确定这些化合物腹腔注射时是否能拮抗士的宁诱发的癫痫发作，并将它们的作用与肌氨酸（N-甲基甘氨酸）和甘氨酸的作用进行比较。甜菜碱、N，N-二甲基甘氨酸和肌氨酸在降低癫痫发作和死亡发生率方面具有同等效力，在剂量为5毫摩尔/千克时，癫痫发作和死亡发生率降低38%至72%。甘氨酸没有作用。因此，通过单次N-甲基化可赋予甘氨酸抗惊厥活性。
