Ghoz E H, Freed W J
Pharmacol Biochem Behav. 1985 Apr;22(4):635-40. doi: 10.1016/0091-3057(85)90287-4.
The ability of betaine to block homocysteine, pentylenetetrazol, and electroshock induced seizures in mice has previously been observed. In this study, betaine administered IP and intraventricularly to rats blocked pentylenetetrazol-induced seizures, but IP betaine did not block audiogenic seizures. Intraventricular betaine was about 1000-fold more potent than IP betaine in blocking PTZ-induced seizures. Glycine, a component of the betaine molecule, was ineffective. It is concluded that betaine has an appreciable but selective effect in controlling experimental seizures in rats. This effect is mediated directly by the brain, and is not due to metabolism of betaine to glycine.
此前已观察到甜菜碱能够阻止同型半胱氨酸、戊四氮和电休克诱发的小鼠癫痫发作。在本研究中，给大鼠腹腔注射和脑室内注射甜菜碱可阻止戊四氮诱发的癫痫发作，但腹腔注射甜菜碱不能阻止听源性癫痫发作。脑室内注射甜菜碱在阻止戊四氮诱发的癫痫发作方面比腹腔注射甜菜碱的效力强约1000倍。甜菜碱分子的成分之一甘氨酸无效。得出的结论是，甜菜碱在控制大鼠实验性癫痫发作方面具有显著但具有选择性的作用。这种作用是由大脑直接介导的，并非由于甜菜碱代谢为甘氨酸所致。
