van Andel Judith, Ungureanu Constantin, Aarts Ronald, Leijten Frans, Arends Johan
Brain Center Rudolf Magnus, University Medical Center Utrecht, Department of Clinical Neurophysiology, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Academic Centre for Epileptology Kempenhaeghe, Department of Clinical Neurophysiology, Sterkselseweg 65, 5591 VE Heeze, The Netherlands; Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands.
Epilepsy Behav. 2015 Apr;45:142-5. doi: 10.1016/j.yebeh.2015.02.018. Epub 2015 Mar 24.
Heart rate is a useful neurophysiological sign when monitoring seizures in patients with epilepsy. In an ambulatory setting, heart rate is measured with ECG involving electrodes on the skin. This method is uncomfortable which is burdensome for patients and is sensitive to motion artifacts, which decrease the usability of measurements. In this study, green light photoplethysmography, an optical technique arising from the fitness industry, was evaluated for usefulness in a medical setting. Simultaneous overnight measurements of HR with a commercially available optical heart rate (OHR) sensor and with ECG (HRECG) were performed in 7 patients with epilepsy. Overall, there was no significant difference between OHR and HRECG in random 10-minute periods during wakefulness (p=0.69) and sleep (p=1.00). The Bland-Altman analysis showed negligible mean differences. Limits of agreement were higher during wakefulness and during the occurrence of two seizures possibly because of less reliable HRECG measurements due to motion artifacts. Optical heart rate seems less sensitive to these motion artifacts, and measurements are more user-friendly. The optical heart rate sensor may fill the gap of systems for ambulatory heart rate monitoring and can be especially useful in the context of seizure detection in patients with epilepsy.
在监测癫痫患者的癫痫发作时，心率是一个有用的神经生理指标。在动态监测环境中，通过连接在皮肤上的电极利用心电图来测量心率。这种方法会让患者感到不适且负担较重，并且对运动伪影敏感，这降低了测量的可用性。在本研究中，对源自健身行业的光学技术——绿光容积脉搏波描记法在医疗环境中的实用性进行了评估。对7例癫痫患者使用商用光学心率（OHR）传感器和心电图（HRECG）同时进行了整夜心率测量。总体而言，在清醒状态下（p = 0.69）和睡眠状态下（p = 1.00）的随机10分钟时间段内，OHR和HRECG之间无显著差异。布兰德-奥特曼分析显示平均差异可忽略不计。在清醒状态下以及两次癫痫发作期间一致性界限较高，这可能是由于运动伪影导致HRECG测量可靠性较低。光学心率似乎对这些运动伪影不太敏感，并且测量对用户更友好。光学心率传感器可能填补动态心率监测系统的空白，在癫痫患者的癫痫发作检测方面可能特别有用。
