通过光电容积描记法测量的全身性癫痫和局灶性癫痫之间早期血流动力学差异。

Early hemodynamic differences between generalized and focal epilepsy measured by photoplethysmography.

作者信息

Mei Aoxue, Fu Cong, Liu Zhao, Yang Yujiao, Wang Xiongfei, Wang Mengyang, Wang Jing, Han Zhigang, Bo Yujie, Xu Ke, Tang Chongyang, Luan Guoming

机构信息

Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, No. 50 Xiang Shan Yi-Ke-Song Road, Haidian District, Beijing, 100093, China.

Department of Neurology, Sanbo Brain Hospital, Capital Medical University, Beijing, 100093, China.

出版信息

Sci Rep. 2025 Jun 4;15(1):19647. doi: 10.1038/s41598-025-02127-3.

DOI:10.1038/s41598-025-02127-3

PMID:40467660

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12137735/

Abstract

Photoplethysmography (PPG) detects hemodynamic changes during epileptic seizures. This study aim to investigate PPG signals changes during generalized tonic‒clonic seizures (GTCSs) and focal impaired awareness seizures (FIASs). 17 GTCS and 19 FIAS episodes were recorded from 18 patients. The 30 min preictal period was divided into three 10-minute intervals. PPG features analyzed were pulse upslope (PUS), maximal compliance (Kmax), and skewness. Features across 3 preictal intervals showed significant reductions compared to the baseline: PUS (F = 11.870, p < 0.001), Kmax (F = 7.419, p < 0.001) and skewness (F = 2.852, p = 0.044) in the GTCS group. PUS (Kruskal-Wallis [K-W] = 22.600, p < 0.001) and Kmax (K-W = 28.110, p < 0.001) in the FIAS group. In the GTCS group, the largest difference was observed 30 min before seizure onset (PUS: p < 0.001, Cohen's d = 1.843; Kmas: p < 0.001, Cohen's d = 1.419; skewness: p = 0.043, Cohen's d = 0.808), whereas this was not the case in the FIAS group. PPG signals showed earlier changes in the GTCS group than in the FIAS group, highlighting their differences and the potential of PPG-based monitoring for early seizure detection.

摘要

光电容积脉搏波描记法（PPG）可检测癫痫发作期间的血流动力学变化。本研究旨在调查全面强直阵挛发作（GTCS）和局灶性意识障碍发作（FIAS）期间PPG信号的变化。记录了18例患者的17次GTCS发作和19次FIAS发作。发作前30分钟分为三个10分钟的时间段。分析的PPG特征包括脉搏上升斜率（PUS）、最大顺应性（Kmax）和偏度。与基线相比，发作前三个时间段的特征均显著降低：GTCS组的PUS（F = 11.870，p < 0.001）、Kmax（F = 7.419，p < 0.001）和偏度（F = 2.852，p = 0.044）。FIAS组的PUS（Kruskal-Wallis [K-W] = 22.600，p < 0.001）和Kmax（K-W = 28.110，p < 0.001）。在GTCS组中，发作前30分钟观察到的差异最大（PUS：p < 0.001，Cohen's d = 1.843；Kmas：p < 0.001，Cohen's d = 1.419；偏度：p = 0.043，Cohen's d = 0.808），而FIAS组则不然。PPG信号在GTCS组中比FIAS组更早出现变化，突出了它们的差异以及基于PPG监测进行癫痫发作早期检测的潜力。