Heinz F X
Wien Klin Wochenschr. 1985 Mar 1;97(5):230-7.
The application of hybridoma technology to the preparation of monoclonal antibodies has had a strong stimulatory effect on many areas of virological research. This development has expanded our knowledge with respect to antigenic variation among viruses and detailed analysis of complex antigenic structures of virus proteins and has also led to the elucidation of the molecular foundations of pathogenesis and virulence in model systems. The practical importance of these results spans many important areas of applied virology such as the development of new viral vaccines, passive immunization and diagnosis of viral infections.
杂交瘤技术在单克隆抗体制备中的应用对病毒学研究的许多领域产生了强大的推动作用。这一进展扩展了我们对病毒间抗原变异以及病毒蛋白复杂抗原结构详细分析的认识，还促成了在模型系统中对发病机制和毒力分子基础的阐明。这些成果的实际重要性涵盖了应用病毒学的许多重要领域，如新型病毒疫苗的研发、被动免疫以及病毒感染的诊断。
