Keiichi Hishikawa, Osamu Takase, Masahiro Yoshikawa, Taro Tsujimura, Masaomi Nangaku, Tsuyoshi Takato, Department of Advanced Nephrology and Regenerative Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
World J Stem Cells. 2015 Mar 26;7(2):490-4. doi: 10.4252/wjsc.v7.i2.490.
Human pluripotent cells are promising for treatment for kidney diseases, but the protocols for derivation of kidney cell types are still controversial. Kidney tissue regeneration is well confirmed in several lower vertebrates such as fish, and the repair of nephrons after tubular damages is commonly observed after renal injury. Even in adult mammal kidney, renal progenitor cell or system is reportedly presents suggesting that adult stem-like cells in kidney can be practical clinical targets for kidney diseases. However, it is still unclear if kidney stem cells or stem-like cells exist or not. In general, stemness is defined by several factors such as self-renewal capacity, multi-lineage potency and characteristic gene expression profiles. The definite use of stemness may be obstacle to understand kidney regeneration, and here we describe the recent broad findings of kidney regeneration and the cells that contribute regeneration.
人多能干细胞在肾脏疾病治疗中有很好的应用前景，但用于肾脏细胞类型诱导的方案仍存在争议。在鱼类等几种低等脊椎动物中，肾脏组织的再生已得到很好的证实，而且在肾损伤后，肾小管损伤后的肾单位修复也很常见。即使在成年哺乳动物的肾脏中，据报道也存在肾祖细胞或系统，这表明肾脏中的成体样干细胞可能是肾脏疾病的实际临床治疗靶点。然而，目前尚不清楚是否存在肾脏干细胞或类干细胞。一般来说，干性通过自我更新能力、多能性和特征基因表达谱等几个因素来定义。对干性的明确应用可能会阻碍对肾脏再生的理解，在此我们描述了肾脏再生和参与再生的细胞的最新广泛发现。
