Cerrato Enrico, Calcagno Andrea, D'Ascenzo Fabrizio, Biondi-Zoccai Giuseppe, Mancone Massimo, Grosso Marra Walter, Demarie Daniela, Omedè Pierluigi, Abbate Antonio, Bonora Stefano, DiNicolantonio James J, Estrada Vicente, Escaned Javier, Moretti Claudio, Gaita Fiorenzo
Division of Cardiology , University of Turin , Turin , Italy (www.cardiogroup.org) ; Wegmans Pharmacy , Ithaca, New York , USA.
Division of Infectious Disease , Amedeo di Savoia Hospital , Turin , Italy.
Open Heart. 2015 Mar 20;2(1):e000174. doi: 10.1136/openhrt-2014-000174. eCollection 2015.
HIV patients are exposed to a higher risk of adverse cardiovascular events, due to complex interactions between traditional risk factors and HIV infection itself in terms of ongoing endothelial dysfunctional immune activation/inflammation and increased risk of thrombosis. On the other hand, long-span antiretroviral therapy administration still raises questions on its long-term safety in an era in which life expectancy is becoming longer and longer while treatment of non-HIV-related serious events is increasingly raising concern. In this article, we will critically analyse the current knowledge of pathological and clinical aspects pertaining to the increased risk of cardiovascular events associated with HIV.
由于传统风险因素与HIV感染本身在持续的内皮功能障碍、免疫激活/炎症以及血栓形成风险增加方面存在复杂的相互作用，HIV患者面临更高的不良心血管事件风险。另一方面，在预期寿命越来越长且非HIV相关严重事件的治疗日益受到关注的时代，长期使用抗逆转录病毒疗法的长期安全性仍存在疑问。在本文中，我们将批判性地分析与HIV相关的心血管事件风险增加相关的病理和临床方面的现有知识。
