全球初治 HIV 感染人群中选定的心血管代谢危险因素流行情况：系统评价和荟萃分析方案。

Prevalence of selected cardiometabolic risk factors in the global ART-naïve HIV infected population: A protocol for a systematic review and meta-analysis.

机构信息

Faculty of Health Sciences, Department of Medicine, University of Cape Town, Western Cape, South Africa.

Clinical Research Education, Networking & Consultancy (CRENC), Douala, Cameroon.

出版信息

PLoS One. 2023 Jun 8;18(6):e0286789. doi: 10.1371/journal.pone.0286789. eCollection 2023.

DOI:10.1371/journal.pone.0286789

PMID:37289750

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10249803/

Abstract

INTRODUCTION

People living with HIV/AIDS (PLHIV) are at increased risk of cardiometabolic diseases attributable to the effects of the virus, antiretroviral therapy (ART) and traditional risk factors. Most studies have focused on assessing the effect of ART on cardiometabolic diseases in PLHIV with fewer studies assessing the cardiometabolic risk profile prior to exposure to ART. Therefore, this protocol is for a systematic review and meta-analysis to estimate the global prevalence of selected cardiometabolic risk factors in ART-naïve PLHIV and their association with HIV specific factors.

METHODS

We shall conduct a systematic search of observational studies on the prevalence of obesity, hypertension, diabetes, and dyslipidaemia in ART-naïve PLHIV and their association with HIV specific characteristics. We will search PubMed-MEDLINE, CINAHL, SCOPUS, Academic Search Premier, Africa-Wide Information and Africa Journals Online databases to identify relevant studies published before June 2022. Two authors will independently screen, select studies, extract data, and conduct risk of bias assessments. Disagreements between the two authors will be resolved by consensus or consulting a third reviewer. Data consistently reported across studies will be pooled using random-effects meta-analysis. Heterogeneity will be evaluated using Cochrane's Q statistic and quantified using I2 statistics. The Preferred Reporting Items for Systematic reviews and Meta-Analysis protocols (PRISMA-P) 2015 guidelines are used for the reporting of this protocol.

DISCUSSION

This review will help determine the burden of selected cardiometabolic diseases in ART-naïve HIV-infected populations and the contribution of HIV infection, independent of ART, to cardiometabolic diseases in PLHIV. It will provide new information that can help orientate future research and potentially guide healthcare policy making. This is part of a thesis that will be submitted to the Faculty of Health Sciences, University of Cape Town, for the award of a PhD in Medicine with protocol ethical clearance number (UCT HREC 350/2021).

REGISTRATION

PROSPERO: CRD42021226001. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021226001.

摘要

简介

艾滋病毒/艾滋病（HIV/AIDS）感染者（PLHIV）由于病毒、抗逆转录病毒疗法（ART）和传统危险因素的影响，患心血管代谢疾病的风险增加。大多数研究都集中在评估 ART 对 PLHIV 心血管代谢疾病的影响，而对 ART 暴露前的心血管代谢风险概况评估较少。因此，本方案是对系统评价和荟萃分析的制定，以估计在未经 ART 治疗的 PLHIV 中选定心血管代谢危险因素的全球流行率及其与 HIV 特异性因素的关系。

方法

我们将对未经 ART 治疗的 PLHIV 中肥胖、高血压、糖尿病和血脂异常的流行率及其与 HIV 特异性特征的关系进行系统搜索。我们将搜索 PubMed-MEDLINE、CINAHL、SCOPUS、Academic Search Premier、Africa-Wide Information 和 Africa Journals Online 数据库，以确定在 2022 年 6 月之前发表的相关研究。两名作者将独立筛选、选择研究、提取数据并进行偏倚风险评估。如果两名作者存在分歧，将通过协商或咨询第三位审稿人解决。对一致报告的数据将使用随机效应荟萃分析进行汇总。使用 Cochrane 的 Q 统计量评估异质性，并使用 I2 统计量量化。本方案将按照系统评价和荟萃分析报告的首选报告项目（PRISMA-P）2015 指南进行报告。

讨论

本综述将有助于确定未经 ART 治疗的 HIV 感染人群中选定心血管代谢疾病的负担，以及 HIV 感染（独立于 ART）对 PLHIV 心血管代谢疾病的贡献。它将提供新的信息，可以帮助确定未来的研究方向，并可能指导医疗保健政策的制定。这是向开普敦大学健康科学学院提交的博士论文的一部分，论文主题为医学博士，方案获得了 UCT HREC 350/2021 的伦理批准。