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[用5%利多卡因药用贴剂治疗乳腺癌术后持续性疼痛]

[Treatment of persistent postmastectomy pain with 5% Lidocaine medicated plaster].

作者信息

Cruto M E, Baricocchi E, Battistella M, Bona F, Giacoletto G, Iacobellis A, Moselli N, Palomba G, Sardo E, Savojardo M, Suita L, Zocca E, Debernardi F

机构信息

IRCCS, Istituto per la Ricerca e la Cura del Cancro Candiolo, Torino, Italia -

出版信息

Minerva Chir. 2015 Apr;70(2):147-53.

Abstract

Persistent postmastectomy pain (PPMP) syndrome is characterized by neuropathic pain that develops following surgery in breast cancer patients. The reported incidence of PPMP ranges between 30% and 50% and is estimated to increase as the number of women surviving cancer continues to rise. Though effective, today's drug treatments are poorly tolerated, limiting their use and reducing adherence to therapy. Since neuropathic pain is localized, international guidelines suggest that topical treatment with 5% Lidocaine medicated plaster either alone or combined with systemic drugs can be considered for pain management. In this retrospective study we reviewed the medical records of 11 patients treated with 5% lidocaine medicated plaster for moderate-to-severe PPMP at our institute between November 2013 and October 2014. Analysis showed that treatment with 5% Lidocaine medicated plaster, either alone or in combination with systemic drugs, achieved significant pain control already after the first week of therapy. The effectiveness and tolerability of 5% Lidocaine medicated plaster we observed suggests that it is a viable option in the management of PPMP.

摘要

乳房切除术后持续性疼痛(PPMP)综合征的特征是乳腺癌患者手术后出现的神经性疼痛。PPMP的报告发病率在30%至50%之间,并且随着癌症存活女性数量的持续增加,预计还会上升。尽管目前的药物治疗有效,但耐受性较差,限制了其使用并降低了治疗依从性。由于神经性疼痛是局部性的,国际指南建议,对于疼痛管理,可以考虑单独使用5%利多卡因药用贴剂或与全身性药物联合使用进行局部治疗。在这项回顾性研究中,我们查阅了2013年11月至2014年10月期间在我院接受5%利多卡因药用贴剂治疗中重度PPMP的11例患者的病历。分析表明,单独使用5%利多卡因药用贴剂或与全身性药物联合使用,在治疗的第一周后就实现了显著的疼痛控制。我们观察到的5%利多卡因药用贴剂的有效性和耐受性表明,它是管理PPMP的一个可行选择。

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