局部用5%利多卡因药贴治疗开胸术后慢性神经病理性疼痛的疗效
Efficacy of the topical 5% lidocaine medicated plaster in the treatment of chronic post-thoracotomy neuropathic pain.
作者信息
Sansone Pasquale, Passavanti Maria Beatrice, Fiorelli Alfonso, Aurilio Caterina, Colella Umberto, De Nardis Lorenzo, Donatiello Valerio, Pota Vincenzo, Pace Maria Caterina
机构信息
Department of Woman, Child, General & Specialized Surgery, University of Campania L. Vanvitelli, Naples, Italy.
Thoracic Surgery Unit, University of Campania L. Vanvitelli, Naples, Italy.
出版信息
Pain Manag. 2017 May;7(3):189-196. doi: 10.2217/pmt-2016-0060. Epub 2017 Mar 3.
AIM
To assess the efficacy of the topical 5% lidocaine medicated plaster (Versatis, Grünenthal GmbH, Aachen, Germany) in patients with post-thoracotomy neuropathic pain.
PATIENTS & METHODS: Patients were randomized to receive the topical 5% lidocaine medicated plaster (n = 33) or non-medicated placebo plasters (n = 30) for 12 h every day for 8 weeks. Laser-evoked potentials (LEPs) were measured, and various questionnaires/scales completed.
RESULTS
Numeric Rating Scale pain scores improved significantly (p < 0.01) more in topical 5% lidocaine medicated plaster than in placebo recipients. The same was true for N2 and P2 LEP latency and amplitude, and other parameters.
CONCLUSION
The study included neurophysiological findings and confirmed the efficacy of the topical 5% lidocaine medicated plaster in patients with chronic post-thoracotomy neuropathic pain.
目的
评估局部用5%利多卡因药用贴剂（优妥，德国亚琛格兰泰有限公司）对开胸术后神经性疼痛患者的疗效。
患者与方法
将患者随机分为两组，一组每天使用局部用5%利多卡因药用贴剂（n = 33），另一组使用无药安慰剂贴剂（n = 30），每天使用12小时，共8周。测量激光诱发电位（LEP），并完成各种问卷/量表。
结果
与接受安慰剂的患者相比，局部用5%利多卡因药用贴剂组的数字评分量表疼痛评分显著改善（p < 0.01）。N2和P2 LEP潜伏期、波幅及其他参数的情况亦是如此。
结论
该研究纳入了神经生理学结果，并证实了局部用5%利多卡因药用贴剂对慢性开胸术后神经性疼痛患者的疗效。
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