Ferber H P, Nitsch E, Förster H
Arzneimittelforschung. 1985;35(3):615-22.
32 volunteers, none of whom showed any symptoms for kidney, liver or pancreas disease, were given by infusion 500 ml of various type of hydroxyethyl starch (HES) at a concentration of 6% (450/0.7, 450/0.5, 450/0.3, 300/0.4) as well as of 10% (200/0.7, 200/0.5, 200/0.3, 200/0.1) over a period of 30 min. After infusion both the Mw and the Mn diminished. The rate of elimination of HES from serum entirely depended on molar substitution and not on Mw. The quotient Mw/Mn decreased considerably over the entire test period. The lower molecular weight limit in serum remained relatively the same at 60,000 Daltons. Maximum molecular weight limit of urine, too, was 60,000 Daltons.
32名志愿者，均未表现出任何肾脏、肝脏或胰腺疾病症状，在30分钟内通过静脉输注给予500毫升不同类型的羟乙基淀粉（HES），浓度分别为6%（450/0.7、450/0.5、450/0.3、300/0.4）以及10%（200/0.7、200/0.5、200/0.3、200/0.1）。输注后，分子量（Mw）和数均分子量（Mn）均降低。HES从血清中的消除速率完全取决于摩尔取代度，而非分子量。在整个测试期间，Mw/Mn比值大幅下降。血清中的较低分子量极限相对保持在60,000道尔顿不变。尿液的最大分子量极限也是60,000道尔顿。
