利用人类胚胎干细胞进行人类营养建模。
Modeling human nutrition using human embryonic stem cells.
机构信息
Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge MA, USA.
Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge MA, USA.
出版信息
Cell. 2015 Mar 26;161(1):12-17. doi: 10.1016/j.cell.2015.02.039.
Nutrition presents unanswered scientific questions of high public health importance. We envision model systems composed of interacting gastrointestinal and metabolic tissues derived from human embryonic stem cells, populated by gut microbiota. The culture will be embedded in 3D scaffolds, creating a controlled experimental system that enables tissue sampling and imaging.
营养提出了具有高度公共卫生重要性的未解答的科学问题。我们设想了由源自人类胚胎干细胞的相互作用的胃肠道和代谢组织组成的模型系统，并由肠道微生物群定植。该培养物将被嵌入 3D 支架中，创建一个允许组织取样和成像的受控实验系统。
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