Chen Yiping, Wang Xiaochen, Chen Guodi, Dong Caixia, Zhang Depu
Department of Psychiatry, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, PR China.
Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, PR China.
PLoS One. 2015 Mar 27;10(3):e0121404. doi: 10.1371/journal.pone.0121404. eCollection 2015.
Matrix metalloproteinase 2 (MMP-2) plays a crucial role in the progression of breast cancer (BC). The prognostic role of MMP-2 expression in BC patients has been widely reported, but the results were inconsistent. Thus, a meta-analysis was conducted to gain a better insight into the impact of MMP-2 expression on survival and clinicopathological features of BC patients.
Identical search strategies were used to search relevant literatures in electronic databases update to August 1, 2014. Individual hazard ratios (HRs) and odds ratios (ORs) with their 95% confidence intervals (CIs) were extracted and pooled to evaluate the strength of the association between positive MMP-2 expression and survival results and clinicopathological features of BC patients. Begg's tests, Egger's tests and funnel plots were used to evaluate publication bias. Heterogeneity and sensitivity analysis were also assessed. All the work was completed using STATA.
Pooled HRs and 95% CIs suggested that MMP-2 expression had an unfavorable impact on both OS (HR: 1.53, 95% CI: 1.29-1.82) and DFS/RFS/DDFS (HR: 1.41, 95% CI: 1.07-1.86) in BC patients. Furthermore, MMP-2 expression was significantly associated with lymph node metastasis (positive vs negative: OR 1.91, 95% CI 1.17-3.12).
In conclusion, positive MMP-2 expression might be a significant predictive factor for poor prognosis in patients with BC.
基质金属蛋白酶2（MMP - 2）在乳腺癌（BC）进展中起关键作用。MMP - 2表达在BC患者中的预后作用已被广泛报道，但结果不一致。因此，进行了一项荟萃分析，以更好地了解MMP - 2表达对BC患者生存及临床病理特征的影响。
采用相同的检索策略在电子数据库中检索截至2014年8月1日的相关文献。提取并汇总个体风险比（HRs）和比值比（ORs）及其95%置信区间（CIs），以评估MMP - 2阳性表达与BC患者生存结果及临床病理特征之间关联的强度。使用Begg检验、Egger检验和漏斗图评估发表偏倚。还评估了异质性和敏感性分析。所有工作均使用STATA完成。
汇总的HRs和95% CIs表明，MMP - 2表达对BC患者的总生存期（OS）（HR：1.53，95% CI：1.29 - 1.82）和无病生存期/无复发生存期/远处无病生存期（DFS/RFS/DDFS）（HR：1.41，95% CI：1.07 - 1.86）均有不利影响。此外，MMP - 2表达与淋巴结转移显著相关（阳性vs阴性：OR 1.91，95% CI 1.17 - 3.12）。
总之，MMP - 2阳性表达可能是BC患者预后不良的重要预测因素。
