Zhang De-Pu, Li Xiao-Wei, Lang Jing-He
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, China E-mail :
Asian Pac J Cancer Prev. 2015;16(14):5625-33. doi: 10.7314/apjcp.2015.16.14.5625.
β-catenin plays a crucial role in the progression of breast cancer (BC) and a prognostic role of in BC patients has been widely reported. However, controversy still remains.
Identical search strategies were used to search relevant literature in electronic databases updated to July 1, 2014. Individual hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted and pooled HRs with 95%CIs were used to evaluate the strength of association between positive β-catenin expression in different subcellular locations and survival results of BC patients. Subgroup and meta-regression analyses were performed to explore heterogeneity. Funnel plots of Begg's and Egger's linear regression test were used to investigate publication bias. Heterogeneity and sensitivity were also assessed. All the work was completed using STATA.
A total of 2,204 patients from 12 evaluative studies were finally included. Pooled HRs and 95%CIs suggested that β-catenin expression in cytoplasm/nucleus had an unfavorable impact on both overall survival (OS) (HR: 1.93, 95%CI: 1.40-2.65) and disease free survival (DFS)/ recurrent free survival (RFS) (HR: 1.60, 95%CI: 1.20-2.13) in BC patients. However, here was no significant association between β-catenin expression in the membranes with OS (HR: 0.65, 95%CI: 0.42-1.02) or DFS/RFS (HR: 0.66, 95%CI: 0.38-1.13). Publication bias was absent in all of the four outcomes. Sensitivity analysis revealed that the results of this meta-analysis were robust.
Positive β-catenin expression in cytoplasm/nucleus rather than in membrane is a significant prognostic factor in patients with BC who have been surgically treated.
β-连环蛋白在乳腺癌（BC）进展中起关键作用，其在BC患者中的预后作用已被广泛报道。然而，争议仍然存在。
采用相同的检索策略在更新至2014年7月1日的电子数据库中检索相关文献。提取个体风险比（HR）和95%置信区间（CI），并使用合并的HR及95%CI来评估不同亚细胞定位中β-连环蛋白阳性表达与BC患者生存结果之间的关联强度。进行亚组分析和Meta回归分析以探讨异质性。使用Begg法和Egger线性回归检验的漏斗图来研究发表偏倚。还评估了异质性和敏感性。所有工作均使用STATA完成。
最终纳入了来自12项评估研究的2204例患者。合并的HR及95%CI表明，细胞质/细胞核中β-连环蛋白表达对BC患者的总生存期（OS）（HR：1.93，95%CI：1.40 - 2.65）和无病生存期（DFS）/无复发生存期（RFS）（HR：1.60，95%CI：1.20 - 2.13）均有不利影响。然而，膜中β-连环蛋白表达与OS（HR：0.65，95%CI：0.42 - 1.02）或DFS/RFS（HR：0.66，95%CI：0.38 - 1.13）之间无显著关联。所有四个结局均不存在发表偏倚。敏感性分析表明该Meta分析结果可靠。
对于接受手术治疗的BC患者，细胞质/细胞核而非膜中β-连环蛋白阳性表达是一个重要的预后因素。
