Memedyarov A M, Namazova-Baranova L S, Ermolina Y V, Anikin A V, Maslova O I, Karkashadze M Z, Klochkova O A
Vestn Ross Akad Med Nauk. 2014(9-10):70-6. doi: 10.15690/vramn.v69i9-10.1134.
Diffusion tensor tractography--a new method of magnetic resonance imaging, that allows to visualize the pathways of the brain and to study their structural-functional state.
The authors investigated the changes in motor and sensory pathways of brain in children with cerebral palsy using routine magnetic resonance imaging and diffusion-tensor tractography.
The main group consisted of 26 patients with various forms of cerebral palsy and the comparison group was 25 people with normal psychomotor development (aged 2 to 6 years) and MR-picture of the brain. Magnetic resonance imaging was performed on the scanner with the induction of a magnetic field of 1,5 Tesla. Coefficients of fractional anisotropy and average diffusion coefficient estimated in regions of the brain containing the motor and sensory pathways: precentral gyrus, posterior limb of the internal capsule, thalamus, posterior thalamic radiation and corpus callosum.
Statistically significant differences (p < 0.05) values of fractional anisotropy and average diffusion coefficient in patients with cerebral palsy in relation to the comparison group. All investigated regions, the coefficients of fractional anisotropy in children with cerebral palsy were significantly lower, and the average diffusion coefficient, respectively, higher.
These changes indicate a lower degree of ordering of the white matter tracts associated with damage and subsequent development of gliosis of varying severity in children with cerebral palsy. It is shown that microstructural damage localized in both motor and sensory tracts that plays a leading role in the development of the clinical picture of cerebral palsy.
扩散张量纤维束成像——一种新的磁共振成像方法，可使大脑通路可视化并研究其结构功能状态。
作者使用常规磁共振成像和扩散张量纤维束成像研究脑瘫患儿大脑运动和感觉通路的变化。
主要组由26例各种形式脑瘫患者组成，对照组为25名精神运动发育正常（年龄2至6岁）且有脑部磁共振图像的人。在1.5特斯拉磁场感应的扫描仪上进行磁共振成像。在包含运动和感觉通路的脑区估计分数各向异性系数和平均扩散系数：中央前回、内囊后肢、丘脑、丘脑后辐射和胼胝体。
脑瘫患者与对照组相比，分数各向异性和平均扩散系数值有统计学显著差异（p < 0.05）。在所有研究区域，脑瘫患儿的分数各向异性系数显著更低，而平均扩散系数则更高。
这些变化表明脑瘫患儿白质束的有序程度较低，与不同严重程度的损伤及随后的胶质增生发展有关。结果表明，微观结构损伤定位于运动和感觉束中，在脑瘫临床表现的发展中起主导作用。
