R.C. Patel Institute of Pharmaceutical Education and Research, Near Karvand Naka, Shirpur, Dhule 425405, Maharashtra, India.
R.C. Patel Institute of Pharmaceutical Education and Research, Near Karvand Naka, Shirpur, Dhule 425405, Maharashtra, India.
Carbohydr Polym. 2015 May 20;122:243-7. doi: 10.1016/j.carbpol.2015.01.018. Epub 2015 Jan 14.
This study aims at application of xyloglucan, polysaccharide polymer as novel film forming agent for ocular delivery of ciprofloxacin. Ciprofloxacin ocular films were prepared by the solvent casting method using xuloglucan (2%). The prepared formulations were evaluated for thickness, percentage drug content, surface pH, swelling, mechanical strength and in vitro drug release. The films were found to be of uniform thickness (0.20 ± 0.07 μm). The % drug content in the films was found to be 95.45 ± 0.25%. The cumulative % drug releases from the formulation was 98.85 at the end of 24h. The formulations followed the anomalous transport release mechanism. Ocular irritancy study reveals safety of formulation to ocular mucosa. Thus, this study suggests that xyloglucan can act as a potential film forming polymer for ocular delivery of a ciprofloxacin.
本研究旨在将木葡聚糖（多糖聚合物）作为一种新型的眼部递药用成膜剂，应用于环丙沙星的眼部给药。通过溶剂浇铸法，使用 2%的木葡聚糖制备环丙沙星眼用膜。对所制备的制剂进行厚度、药物含量百分比、表面 pH 值、溶胀度、机械强度和体外药物释放度的评价。结果表明，所制备的膜具有均匀的厚度（0.20 ± 0.07 μm），药物含量百分比为 95.45 ± 0.25%，在 24 小时内，制剂的累积药物释放度为 98.85%。该制剂符合非定常传输释放机制。眼部刺激性研究表明，该制剂对眼黏膜是安全的。因此，本研究表明，木葡聚糖可用作眼部递药用环丙沙星的潜在成膜聚合物。
