Universidade Federal do Rio Grande - FURG, Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Rua Visconde de Paranaguá 102 Centro, Rio Grande, RS 96203-900, Brazil.
Universidade Federal do Rio Grande - FURG, Programa de Pós-Graduação em Ciências da Saúde, Instituto de Ciências Biológicas, Av. Itália km 8 Bairro Carreiros, Rio Grande, RS 96203-900, Brazil.
Sci Total Environ. 2015 Jul 1;520:206-12. doi: 10.1016/j.scitotenv.2015.02.088. Epub 2015 Mar 25.
Soil is a highly complex material, and because of rapid population growth, intense industrial activity and petrochemical development, it has suffered from contamination with substances of various origins. These environmental contaminants may have detrimental effects on human health, particularly during development. Due to the ability to transmit contaminants to the fetus, evaluating the effects of exposure of pregnant women on the psychomotor development of their offspring is of particular interest. Therefore, this study aimed to investigate the effects of exposure of female rats to an urban soil influenced by the dispersion of air contaminants during periods of pre-pregnancy, pregnancy and lactation on offspring development. Using physiological, behavioral and hematological parameters, deleterious effects on offspring were assessed. In behavioral parameters, parental exposure during pregnancy and lactation resulted in no significant differences in the evaluated parameters when compared to the control group. In contrast, pups from the pre-pregnancy group displayed decreased locomotor and exploratory activity in addition to increased levels of anxiety. Furthermore, offspring of rats exposed to contaminated urban soil during pre-pregnancy demonstrated significant changes in weight gain and development length and a reduction in the number of platelets compared to controls. Significantly, pups born to mothers exposed to contaminated urban soil during the pregnancy displayed changes in birth weight, weight gain during the growth, development length, incisor eruption and opening of the ears in addition to a reduction in their physical performance and a change in the number of lymphocytes. These results clearly show the negative influence of parental exposure to contaminated urban soil on the general development of the rats during the periods studied. These data indicate that developing organisms are highly sensitive to external factors. Further, they demonstrate the utility of these various biomarkers for identifying and displaying toxic effects of exposure to contaminated soils.
土壤是一种高度复杂的物质，由于人口的快速增长、工业活动的加剧和石化工业的发展，它受到了各种来源的物质的污染。这些环境污染物可能对人类健康产生有害影响，尤其是在发育过程中。由于能够将污染物传递给胎儿，因此评估孕妇暴露对其后代的精神运动发育的影响特别重要。因此，本研究旨在调查在妊娠前、妊娠和哺乳期期间暴露于受空气污染物扩散影响的城市土壤中的雌性大鼠对后代发育的影响。使用生理、行为和血液学参数评估对后代的有害影响。在行为参数方面，与对照组相比，妊娠和哺乳期的母体暴露在评估的参数中没有显着差异。相比之下，来自妊娠前组的幼鼠表现出运动和探索活动减少以及焦虑水平增加。此外，与对照组相比，在妊娠前暴露于受污染城市土壤的大鼠的后代体重增加和发育长度减少，血小板数量减少。值得注意的是，暴露于受污染城市土壤的母亲所生的幼鼠在出生体重、生长期间体重增加、发育长度、出牙和耳朵张开方面发生了变化，此外，它们的身体性能降低，淋巴细胞数量发生变化。这些结果清楚地表明，母体暴露于受污染的城市土壤对研究期间大鼠的一般发育有负面影响。这些数据表明，发育中的生物体对外部因素非常敏感。此外，它们还证明了这些各种生物标志物在识别和显示暴露于污染土壤的毒性影响方面的效用。
