Kainu A, Timonen K L, Toikka J, Qaiser B, Pitkäniemi J, Kotaniemi J T, Lindqvist A, Vanninen E, Länsimies E, Sovijärvi A R A
Department of Pulmonary Medicine, HUCH Heart and Lung Center, Peijas Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Department of Clinical Physiology, Central Hospital of Central Finland, Jyväskylä, Finland.
Clin Physiol Funct Imaging. 2016 Sep;36(5):346-58. doi: 10.1111/cpf.12237. Epub 2015 Mar 27.
Diagnostic assessment of lung function necessitates up-to-date reference values. The aim of this study was to estimate reference values for spirometry for the Finnish population between 18 and 80 years and to compare them with the existing Finnish, European and the recently published global GLI2012 reference values.
Spirometry was performed for 1380 adults in the population-based FinEsS studies and for 662 healthy non-smoking volunteer adults. Detailed predefined questionnaire screening of diseases and symptoms, and quality control of spirometry yielded a sample of 1000 native Finns (387 men) healthy non-smokers aged 18-83 years. Sex-specific reference values, which are estimated using the GAMLSS method and adjusted for age and height, are provided.
The predicted values for lung volumes are larger than those obtained by GLI2012 prediction for the Caucasian subgroup for forced vital capacity (FVC) by an average 6·2% and 5·1% and forced expiratory volume in 1 s (FEV1) by an average 4·2% and 3·0% in men and women, respectively. GLI2012 slightly overestimated the ratio FEV1/FVC with an age-dependent trend. Most reference equations from other European countries, with the exception of the Swiss SAPALDIA study, showed an underestimation of FVC and FEV1 to varying degrees, and a slight overestimation of FEV1/FVC.
This study offers up-to-date reference values of spirometry for native Finns with a wide age range. The GLI2012 predictions seem not to be suitable for clinical use for native Finns due to underestimation of lung volumes.
肺功能的诊断评估需要最新的参考值。本研究的目的是估计18至80岁芬兰人群肺活量测定的参考值，并将其与现有的芬兰、欧洲以及最近公布的全球GLI2012参考值进行比较。
在基于人群的FinEsS研究中，对1380名成年人进行了肺活量测定，并对662名健康的非吸烟成年志愿者进行了测定。通过详细的预定义问卷筛查疾病和症状，并对肺活量测定进行质量控制，得到了1000名18 - 83岁的芬兰健康非吸烟原住民（387名男性）样本。提供了使用GAMLSS方法估计并根据年龄和身高进行调整的性别特异性参考值。
肺容积的预测值高于GLI2012对白种人亚组预测的数值，男性和女性的用力肺活量（FVC）平均分别高6.2%和5.1%，1秒用力呼气容积（FEV1）平均分别高4.2%和3.0%。GLI2012对FEV1/FVC比值略有高估，且呈年龄依赖性趋势。除瑞士SAPALDIA研究外，其他欧洲国家的大多数参考方程均不同程度地低估了FVC和FEV1，并略微高估了FEV1/FVC。
本研究提供了广泛年龄范围的芬兰原住民肺活量测定的最新参考值。由于低估了肺容积，GLI2012的预测似乎不适用于芬兰原住民的临床应用。
