Ikeda Masahiro, Matsuzaki Toshiyuki
Department of Veterinary Pharmacology, University of Miyazaki, Miyazaki, Japan.
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Vitam Horm. 2015;98:307-37. doi: 10.1016/bs.vh.2014.12.008. Epub 2015 Feb 14.
Vasopressin is the main hormone that regulates water conservation in mammals and one of its major targets is the principal cells in the renal collecting duct. Vasopressin increases the apical water permeability of principal cells, mediated by apical accumulation of aquaporin-2 (AQP2), a water channel protein, thus facilitating water reabsorption by the kidney. The mechanisms underlying the accumulation of AQP2 in response to vasopressin include vesicular trafficking from intracellular storage vesicles expressing AQP2 within several tens of minutes (short-term regulation) and protein expression of AQP2 over a period of hours to days (long-term regulation). This chapter reviews vasopressin signaling in the kidney, focusing on the molecular mechanisms of short- and long-term regulations of AQP2 expression.
血管加压素是调节哺乳动物水潴留的主要激素，其主要作用靶点之一是肾集合管主细胞。血管加压素通过水通道蛋白2（AQP2，一种水通道蛋白）在顶端的积聚，增加主细胞顶端的水通透性，从而促进肾脏对水的重吸收。血管加压素作用下AQP2积聚的机制包括在数十分钟内从表达AQP2的细胞内储存囊泡进行囊泡运输（短期调节）以及在数小时至数天内AQP2的蛋白质表达（长期调节）。本章综述了肾脏中的血管加压素信号传导，重点关注AQP2表达的短期和长期调节的分子机制。
