在一项临床测量分析中，发现三维立体摄影测量法在临床研究中测量瘢痕体积方面可靠且有效。
In a clinimetric analysis, 3D stereophotogrammetry was found to be reliable and valid for measuring scar volume in clinical research.
作者信息
Stekelenburg Carlijn M, Jaspers Mariëlle E H, Niessen Frank B, Knol Dirk L, van der Wal Martijn B A, de Vet Henrica C W, van Zuijlen Paul P M
机构信息
Burn Center Department, Red Cross Hospital, Vondellaan 13, Beverwijk 1942 LE, The Netherlands; Association of Dutch Burn Centers, Zeestraat 27-29, Beverwijk 1941 AJ, The Netherlands; Department of Plastic, Reconstructive and Hand Surgery, Red Cross Hospital, Vondellaan 13, Beverwijk 1942 LE, The Netherlands; Department of Plastic, Reconstructive and Hand Surgery, VU Medical Center, PO Box 7057, De Boelelaan 1117, Amsterdam 1007 MB, The Netherlands; Research Institute MOVE Department VU University Medical Center of Amsterdam, PO Box 7057, De Boelelaan 1117, Amsterdam 1007 MB, The Netherlands.
Department of Plastic, Reconstructive and Hand Surgery, VU Medical Center, PO Box 7057, De Boelelaan 1117, Amsterdam 1007 MB, The Netherlands.
出版信息
J Clin Epidemiol. 2015 Jul;68(7):782-7. doi: 10.1016/j.jclinepi.2015.02.014. Epub 2015 Feb 28.
OBJECTIVES
Volume is an important feature in the evaluation of hypertrophic scars and keloids. Three-dimensional (3D) stereophotogrammetry is a noninvasive technique for the measurement of scar volume. This study evaluated the reliability and validity of 3D stereophotogrammetry for measuring scar volume.
STUDY DESIGN AND SETTING
To evaluate reliability, 51 scars were photographed by two observers. Interobserver reliability was assessed by the intraclass correlation coefficient (ICC), and the measurement error was expressed as limits of agreement (LoA). To assess validity, 60 simulated (clay) scars were measured by 3D stereophotogrammetry and subsequently weighed (gold standard). The correlation of volumes obtained by both measures was calculated by a concordance correlation coefficient (CCC), and the measurement error was expressed as a 95% prediction interval.
RESULTS
The ICC was 0.99, corresponding to a high correlation of measurements between two observers, although the LoA were relatively wide. The correlation between 3D stereophotogrammetry and the gold standard was also high, with a CCC of 0.97. Again, the plot of the differences and LoA showed moderate agreement for the validity.
CONCLUSION
Three-dimensional stereophotogrammetry is suitable for the use in clinical research but not for the follow-up of the individual patient.
目的
体积是评估增生性瘢痕和瘢痕疙瘩的一项重要特征。三维（3D）立体摄影测量法是一种用于测量瘢痕体积的非侵入性技术。本研究评估了3D立体摄影测量法测量瘢痕体积的可靠性和有效性。
研究设计与设置
为评估可靠性，两名观察者对51处瘢痕进行了拍照。通过组内相关系数（ICC）评估观察者间的可靠性，测量误差以一致性界限（LoA）表示。为评估有效性，通过3D立体摄影测量法对60个模拟（黏土）瘢痕进行测量，随后称重（金标准）。通过一致性相关系数（CCC）计算两种测量方法所得体积的相关性，测量误差以95%预测区间表示。
结果
ICC为0.99，表明两名观察者之间的测量具有高度相关性，尽管LoA相对较宽。3D立体摄影测量法与金标准之间的相关性也很高，CCC为0.97。同样，差异图和LoA显示有效性具有中等一致性。
结论
三维立体摄影测量法适用于临床研究，但不适用于个体患者的随访。
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