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一种用于治疗颏下丰满的新型脱氧胆酸给药方法:通过三维立体摄影测量法评估的病例报告。

A novel approach for deoxycholic acid administration to treat submental fullness: A case report assessed by 3D stereophotogrammetry.

作者信息

Rogerio Victor, Rabelo Viviane, Roschel Pietra, Sakemi Tatiane, Germani Marcelo, Munoz-Lora Victor R M

机构信息

Let's HOF Academy, São Paulo, Brazil.

Department of Periodontology and Implantology, Guarulhos University, São Paulo, Brazil.

出版信息

J Oral Biol Craniofac Res. 2024 May-Jun;14(3):280-283. doi: 10.1016/j.jobcr.2024.03.011. Epub 2024 Mar 29.

DOI:10.1016/j.jobcr.2024.03.011
PMID:38586285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10998212/
Abstract

BACKGROUND

While effective, DAc injections for submental fat (SMF) reduction carry risks, including vascular damage and skin necrosis when improperly administered. This study presents a novel approach to SMF reduction using blunt microcannulas for DAc injections, coupled with 3D stereophotogrammetry quantification (3D-SQ).

CLINICAL PRESENTATION

A 47-year-old female with SMF underwent two DAc applications. 3D-SQ was performed before and after each treatment using a 3D-SQ system. The patient experienced a substantial total volume reduction of 14.81 mL in the submental area after two DAc applications. 3D-SQ analysis showed a gradual reduction in submental volume over time. Importantly, no serious adverse events were reported, with only minor pain and warmth at the treated site. The reduction of SMF through DAc injections involves adipocyte cell lysis, emphasizing the importance of proper injection technique to avoid adverse events. The use of blunt microcannulas offers a safer alternative, minimizing the risk of skin necrosis, ulceration, and intra-arterial injections. Additionally, cannulas reduce bruising due to their blunt design and fan technique, enhancing patient comfort and safety.

CONCLUSION

This case report highlights the efficacy of a novel cannula approach for DAc SMF reduction, assessed by 3D-SQ. Blunt microcannulas may represent a safer option compared to hypodermic needles, reducing the likelihood of severe complications.

摘要

背景

虽然用于减少颏下脂肪(SMF)的去氧胆酸(DAc)注射有效,但操作不当会带来风险,包括血管损伤和皮肤坏死。本研究提出了一种使用钝头微套管进行DAc注射以减少SMF的新方法,并结合三维立体摄影测量量化法(3D-SQ)。

临床表现

一名患有颏下脂肪的47岁女性接受了两次DAc注射。每次治疗前后均使用3D-SQ系统进行三维立体摄影测量量化。两次DAc注射后,患者颏下区域的总体积大幅减少了14.81毫升。三维立体摄影测量量化分析显示,颏下体积随时间逐渐减少。重要的是,未报告严重不良事件,仅治疗部位有轻微疼痛和温热感。通过DAc注射减少颏下脂肪涉及脂肪细胞溶解,强调了正确注射技术以避免不良事件的重要性。使用钝头微套管提供了一种更安全的选择,可将皮肤坏死、溃疡和动脉内注射的风险降至最低。此外,套管因其钝头设计和扇形技术减少了瘀伤,提高了患者的舒适度和安全性。

结论

本病例报告强调了一种通过三维立体摄影测量量化评估的用于DAc减少颏下脂肪的新型套管方法的有效性。与皮下注射针头相比,钝头微套管可能是一种更安全的选择,可降低严重并发症的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f647/10998212/93b9d826dc33/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f647/10998212/f9c2e80ea225/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f647/10998212/8e957b5f2f01/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f647/10998212/8e328ca64827/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f647/10998212/19c3b04d7d54/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f647/10998212/93b9d826dc33/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f647/10998212/f9c2e80ea225/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f647/10998212/8e957b5f2f01/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f647/10998212/8e328ca64827/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f647/10998212/19c3b04d7d54/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f647/10998212/93b9d826dc33/gr4.jpg

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Clinics (Sao Paulo). 2023 Oct 6;78:100220. doi: 10.1016/j.clinsp.2023.100220. eCollection 2023.
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Is deoxycholic acid able to reduce submental fat and increase patient satisfaction when compared to placebo groups? A systematic review.与安慰剂组相比,脱氧胆酸是否能够减少颏下脂肪并提高患者满意度?一项系统评价。
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