Verdoia Monica, Barbieri Lucia, Di Giovine Gabriella, Marino Paolo, Suryapranata Harry, De Luca Giuseppe
Department of Cardiology, Ospedale "Maggiore della Carità", Eastern Piedmont University, Novara, Italy.
Department of Cardiology, UMC St Radboud, Nijmegen, the Netherlands.
Angiology. 2016 Jan;67(1):75-82. doi: 10.1177/0003319715577529. Epub 2015 Mar 29.
The neutrophil to lymphocyte ratio (NLR), an inflammatory biomarker, may be of predictive and prognostic value for cardiovascular (CV) events. We evaluated the relationship of NLR with the prevalence and extent of coronary artery disease (CAD) in consecutive patients undergoing elective or urgent coronary angiography. Our population (n = 3738 patients) was divided into NLR quartiles. Higher NLR was associated with aging and established CV risk factors, previous percutaneous coronary revascularization, acute presentation, and more complex pharmacological therapy. The NLR was related to platelet count, white blood cell count, creatinine, glycemia, uric acid, and C-reactive protein (all P = .001) levels but inversely related to hemoglobin (P < .001), total cholesterol (P = .005), and triglycerides (P < .001) levels. The NLR was associated with multivessel disease (P < .001), anterior descending, right coronary arteries (P < .001) or circumflex branch lesions (P = .01), percentage of stenosis (P < .001), coronary calcification (P < .001), and intracoronary thrombus (P < .001) but inversely with in-stent restenosis (P < .001) and thrombolysis in myocardial infarction flow (P = .04). The NLR was directly related to the prevalence of CAD (P = .001) and severe CAD (P < .001). In patients undergoing coronary angiography, the NLR is independently associated with the prevalence and severity of CAD.
中性粒细胞与淋巴细胞比值（NLR）作为一种炎症生物标志物，可能对心血管（CV）事件具有预测和预后价值。我们评估了连续接受择期或急诊冠状动脉造影患者中NLR与冠状动脉疾病（CAD）患病率及病变程度之间的关系。我们的研究人群（n = 3738例患者）被分为NLR四分位数组。较高的NLR与衰老、已确定的心血管危险因素、既往经皮冠状动脉血运重建、急性发病以及更复杂的药物治疗相关。NLR与血小板计数、白细胞计数、肌酐、血糖、尿酸和C反应蛋白（所有P = 0.001）水平相关，但与血红蛋白（P < 0.001）、总胆固醇（P = 0.005）和甘油三酯（P < 0.001）水平呈负相关。NLR与多支血管病变（P < 0.001）、前降支、右冠状动脉（P < 0.001）或回旋支病变（P = 0.01）、狭窄百分比（P < 0.001）、冠状动脉钙化（P < 0.001）和冠状动脉内血栓（P < 0.001）相关，但与支架内再狭窄（P < 0.001）和心肌梗死溶栓血流（P = 0.04）呈负相关。NLR与CAD患病率（P = 0.001）和严重CAD（P < 0.001）直接相关。在接受冠状动脉造影检查的患者中，NLR与CAD的患病率和严重程度独立相关。
