Zhang Man, Sun Yinuo, Zhang Limeng, Xu Yu, Liu Yifan, Li Kun
Department of Nuclear Medicine, The First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, 250014, China.
Nucl Med Commun. 2025 Jan 1;46(1):1-6. doi: 10.1097/MNM.0000000000001907. Epub 2024 Oct 4.
White blood cells, neutrophils, lymphocytes, and neutrophil-to-lymphocyte ratio (NLR) distribution patterns in patients with anatomic coronary disease have previously been associated with cardiac events such as myocardial infarct size, complications, and prognosis. However, it remains unknown whether myocardial perfusion mass defect percentage (MDP) obtained from gated myocardial perfusion imaging (G-MPI) correlates with these hematological parameters. Therefore, our research aimed to investigate the application of MDP in the evaluation of acute coronary syndrome (ACS).
Thirty-six patients with ACS underwent single-photon emission computed tomography/computed tomography using retrospective electrocardiography gating during the resting state. The primary outcome was the percentage of left ventricular mass with abnormal myocardial perfusion (i.e. MDP) in G-MPI. Furthermore, the correlation between myocardial perfusion MDP and lymphocyte count, neutrophil count, white blood cell count, and NLR was calculated. In addition, we explored the relationship of myocardial perfusion MDP with other cardiac function parameters obtained from G-MPI, such as summed rest score, left ventricular ejection fraction, end-systolic volume, and end-diastolic volume.
Myocardial perfusion MDP significantly correlated with white blood cell count, neutrophil count, and NLR ( P < 0.01). Furthermore, these hematological parameters were significantly different between low and high MDP groups. Additionally, myocardial perfusion MDP negatively correlated with end-systolic volume ( r = -0.615) and left ventricular ejection fraction ( r = -0.657).
Myocardial perfusion MDP has a high correlation with inflammatory cell counts and cardiac function parameters obtained from G-MPI in ACS; this may be of help in the evaluation and treatment of these patients.
既往研究表明，解剖性冠心病患者的白细胞、中性粒细胞、淋巴细胞及中性粒细胞与淋巴细胞比值（NLR）分布模式与心肌梗死面积、并发症及预后等心脏事件相关。然而，门控心肌灌注显像（G-MPI）获得的心肌灌注质量缺损百分比（MDP）是否与这些血液学参数相关仍不清楚。因此，我们的研究旨在探讨MDP在急性冠状动脉综合征（ACS）评估中的应用。
36例ACS患者在静息状态下采用回顾性心电图门控进行单光子发射计算机断层扫描/计算机断层扫描。主要观察指标为G-MPI中心肌灌注异常（即MDP）的左心室质量百分比。此外，计算心肌灌注MDP与淋巴细胞计数、中性粒细胞计数、白细胞计数及NLR之间的相关性。另外，我们探讨了心肌灌注MDP与G-MPI获得的其他心功能参数之间的关系，如静息总积分、左心室射血分数、收缩末期容积和舒张末期容积。
心肌灌注MDP与白细胞计数、中性粒细胞计数及NLR显著相关（P < 0.01）。此外，低MDP组和高MDP组之间这些血液学参数存在显著差异。另外，心肌灌注MDP与收缩末期容积（r = -0.615）和左心室射血分数（r = -0.657）呈负相关。
心肌灌注MDP与ACS患者G-MPI获得的炎症细胞计数和心功能参数高度相关；这可能有助于这些患者的评估和治疗。
