动脉粥样硬化性心血管疾病患者与仅具有心血管疾病风险者的血液学参数：一项比较性横断面研究。
Haematological Parameters in People with Atherosclerotic Cardiovascular Disease versus Those Who are Only at Risk for Cardiovascular Disease: A Comparative Cross-Sectional Study.
作者信息
Abate Ebsitu, Degef Maria, Melkie Addisu, Gnanasekeran Natesan, Mehdi Mohammed, Tolcha Yosef, Chala Dawit
机构信息
Department of Medical Biochemistry Addis Ababa University, Addis Ababa, Ethiopia.
Department of Internal Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
出版信息
Diabetes Metab Syndr Obes. 2023 Jun 23;16:1869-1883. doi: 10.2147/DMSO.S407480. eCollection 2023.
INTRODUCTION
Cardiovascular disease (CVD) is the foremost killer disease worldwide. ASCVD is one of the most common types of CVD. It is mainly associated with a condition called atherosclerosis. Its occurrence is linked to several risk factors. Hypertension, diabetes, dyslipidemia, smoking, genetic factors, and so on are examples. The presence of ASCVD, as well as its risk factors, causes a variety of disruptions in the body's physiological and biological functions. The presence of abnormal physiological and biological functions, for example, tends to disrupt hematological parameters.
PURPOSE
The study's aim was to assess and compare the pattern of hematological parameters in people with established atherosclerotic cardiovascular disease (ASVD) versus people with ASCVD risks alone who attended TASH Addis Ababa, Ethiopia, as well as to correlate hematological parameters with the novel inflammatory marker hs-CRP.
METHODS
A prospective cross-sectional comparative study with 100 study participants was conducted during where October 2019-March 2020 proposal development, sample collection, and lab analysis period, and from March 2020-June to 2021 data entry, analysis, and writing period. A serum sample was collected from each study participant for the lipid and hsCRP analyses and whole blood for hematological parameter determination. The socio-demographic characteristics of the study participants were obtained through a well-structured questionnaire.
RESULTS
The ASCVD-risk group had significantly higher mean platelet volume (MPV), which was associated with the presence of the risk. Furthermore, hs-CRPs show a significant correlation with MPV in a correlation analysis of highly sensitive C-reactive protein (hs-CRP) with hematological parameters. Thus, using these affordable, routinely tested, and easily available tests may help to infer future ASCVD risk as well as the presence of ASCVD morbidity while hsCRP level in comparison group vs cases requires further study.
引言
心血管疾病（CVD）是全球首要的致命疾病。动脉粥样硬化性心血管疾病（ASCVD）是最常见的心血管疾病类型之一。它主要与一种称为动脉粥样硬化的病症相关。其发生与多种风险因素有关。例如高血压、糖尿病、血脂异常、吸烟、遗传因素等。ASCVD及其风险因素的存在会导致身体生理和生物学功能出现各种紊乱。例如，异常生理和生物学功能的存在往往会扰乱血液学参数。
目的
本研究的目的是评估和比较患有已确诊动脉粥样硬化性心血管疾病（ASVD）的人与仅具有ASCVD风险的人在埃塞俄比亚亚的斯亚贝巴塔什就诊时的血液学参数模式，并将血液学参数与新型炎症标志物高敏C反应蛋白（hs-CRP）相关联。
方法
在2019年10月至2020年3月的方案制定、样本采集和实验室分析期间，以及2020年3月至2021年6月的数据录入、分析和撰写期间，对100名研究参与者进行了一项前瞻性横断面比较研究。从每位研究参与者采集血清样本用于血脂和hsCRP分析，采集全血用于血液学参数测定。通过一份结构良好的问卷获取研究参与者的社会人口学特征。
结果
ASCVD风险组的平均血小板体积（MPV）显著更高，这与风险的存在相关。此外，在高敏C反应蛋白（hs-CRP）与血液学参数的相关性分析中，hs-CRPs与MPV显示出显著相关性。因此，使用这些价格低廉、常规检测且易于获得的检测方法可能有助于推断未来的ASCVD风险以及ASCVD发病情况，而比较组与病例组之间hsCRP水平的差异需要进一步研究。
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