Anderson G M, Hoder E L, Shaywitz B A, Cohen D J
Dev Med Child Neurol. 1985 Apr;27(2):207-14. doi: 10.1111/j.1469-8749.1985.tb03771.x.
The amino-acid precursors tryptophan and tyrosine, and the major metabolites 5-hydroxyindoleacetic acid, indoleacetic acid, homovanillic acid and 3-methoxy-4-hydroxyphenethyleneglycol, related to the central neurotransmitters serotonin, dopamine and norepinephrine, were measured in 62 samples of cerebrospinal fluid from human neonates. Means are reported for the samples from 17 medically uncomplicated infants and for the larger group (42 to 45) of infants with medical complications. The latter group was divided according to diagnosis and medication. All groups had significantly higher levels of all compounds in comparison with older children and adults. There were few significant subgroup differences in the group with complications. In both the normal and complicated groups a number of significant correlations were observed between the compounds themselves and with other physiological measures.
对62份人类新生儿脑脊液样本中与中枢神经递质血清素、多巴胺和去甲肾上腺素相关的氨基酸前体色氨酸和酪氨酸，以及主要代谢产物5-羟吲哚乙酸、吲哚乙酸、高香草酸和3-甲氧基-4-羟基苯乙二醇进行了测定。报告了17名无医学并发症婴儿样本以及患有医学并发症的较大组（42至45名）婴儿样本的均值。后一组根据诊断和用药情况进行了划分。与年龄较大的儿童和成人相比，所有组中所有化合物的水平均显著更高。并发症组中几乎没有显著的亚组差异。在正常组和并发症组中，均观察到这些化合物自身之间以及与其他生理指标之间存在一些显著的相关性。
