Møller S E, Mortensen E L, Breum L, Alling C, Larsen O G, Bøge-Rasmussen T, Jensen C, Bennicke K
Research Institute of Biological Psychiatry, St Hans Hospital, Roskilde, Denmark.
Psychol Med. 1996 Mar;26(2):323-31. doi: 10.1017/s0033291700034711.
Associations in 52 normal individuals were examined between plasma and cerebrospinal fluid (CSF) concentrations of tryptophan (Trp) and tyrosine, and concentrations of monoamine metabolites in the CSF, and scores on an aggression questionnaire, the Kinsey Institute Reaction List II, and the Eysenck Personality Questionnaire. There was a significantly positive correlation between CSF 5-hydroxyindoleacetic acid (5-HIAA) levels and extroverted aggression scores, and a significantly negative correlation between CSF 5-HIAA levels and introverted aggression scores. Males showed higher plasma Trp concentrations than females, and significantly positive correlations between plasma Trp concentrations and scores on extroverted aggression and the Eysenck E scale. Males, furthermore, showed a significantly negative correlation between CSF Trp levels and scores on the Eysenck P scale, and a significantly positive correlation between concentrations of 3-methoxy-4-hydroxy-phenylglycol in CSF and scores on moral aggression. These results suggest that central serotonin influences aggression in normal individuals through effects on personality.
在52名正常个体中，研究了血浆和脑脊液（CSF）中色氨酸（Trp）和酪氨酸的浓度、脑脊液中单胺代谢物的浓度，以及攻击性问卷（金赛研究所反应列表II）和艾森克人格问卷的得分之间的关联。脑脊液中5-羟吲哚乙酸（5-HIAA）水平与外向攻击性得分之间存在显著正相关，脑脊液中5-HIAA水平与内向攻击性得分之间存在显著负相关。男性的血浆Trp浓度高于女性，血浆Trp浓度与外向攻击性得分和艾森克E量表得分之间存在显著正相关。此外，男性脑脊液中Trp水平与艾森克P量表得分之间存在显著负相关，脑脊液中3-甲氧基-4-羟基苯乙二醇浓度与道德攻击性得分之间存在显著正相关。这些结果表明，中枢5-羟色胺通过对人格的影响来影响正常个体的攻击性。
