Llabre Maria M, Arguelles William, Schneiderman Neil, Gallo Linda C, Daviglus Martha L, Chambers Earle C, Sotres-Alvarez Daniela, Chirinos Diana A, Talavera Gregory A, Castaneda Sheila F, Roesch Scott C, Heiss Gerardo
Department of Psychology, University of Miami, Coral Gables, FL.
Department of Psychology, University of Miami, Coral Gables, FL.
Ann Epidemiol. 2015 Jul;25(7):480-5. doi: 10.1016/j.annepidem.2015.02.010. Epub 2015 Feb 19.
Metabolic syndrome (MetS), the clustering of several risk factors for cardiovascular disease, is highly prevalent in Hispanics/Latinos. We tested whether all components significantly loaded on the syndrome in Hispanics/Latinos and whether their contribution differed by sex and Hispanic ancestry. We also examined associations of MetS with prevalent diabetes and coronary heart disease in Hispanics/Latinos.
Data were obtained from a population-based cohort of n = 15,823 participants in the HCHS/SOL study who self-identified as being of Central American, Cuban, Dominican, Mexican American, Puerto Rican, or South American ancestry and were aged 18 to 74 years at screening.
A latent variable model of waist circumference, systolic and diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol (HDL-C), and fasting glucose fit the data in men and women, but the contribution of HDL-C was weak. No difference in the latent model of MetS was detected across Hispanic/Latino ancestry groups. MetS was significantly associated with diabetes and coronary heart disease.
Our results indicate that similar criteria for MetS may be applied across Hispanic/Latino ancestry groups but call into question the role of HDL-C in classifying the MetS in Hispanics/Latinos.
代谢综合征（MetS）是心血管疾病多种危险因素的聚集，在西班牙裔/拉丁裔人群中高度流行。我们测试了西班牙裔/拉丁裔人群中所有组分是否都显著负荷于该综合征，以及它们的贡献是否因性别和西班牙裔血统而异。我们还研究了西班牙裔/拉丁裔人群中MetS与糖尿病和冠心病的关联。
数据来自HCHS/SOL研究中一个基于人群的队列，该队列有n = 15823名参与者，他们自我认定为中美洲、古巴、多米尼加、墨西哥裔美国人、波多黎各或南美血统，筛查时年龄在18至74岁之间。
腰围、收缩压和舒张压、甘油三酯、高密度脂蛋白胆固醇（HDL-C）和空腹血糖的潜在变量模型符合男性和女性的数据，但HDL-C的贡献较弱；在不同西班牙裔/拉丁裔血统组中未检测到MetS潜在模型的差异；MetS与糖尿病和冠心病显著相关。
我们的结果表明，MetS的类似标准可应用于不同西班牙裔/拉丁裔血统组，但对HDL-C在西班牙裔/拉丁裔人群中MetS分类中的作用提出了质疑。
