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小儿宫颈卵黄囊瘤的多模式管理

Multimodal management of a pediatric cervical yolk sac tumor.

作者信息

Saltzman Amanda F, Gills Jessie R R, LeBlanc Dana M, Velez Maria C, Craver Randall D, Roth Christopher C

机构信息

Department of Urology, Louisiana State University Health Sciences Center, New Orleans, LA.

Department of Hematology/Oncology, Children's Hospital of New Orleans, New Orleans, LA.

出版信息

Urology. 2015 May;85(5):1186-1189. doi: 10.1016/j.urology.2015.01.034. Epub 2015 Mar 25.

DOI:10.1016/j.urology.2015.01.034
PMID:25818907
Abstract

Even though vaginal bleeding is an unusual clinical presentation in infants and young children, thorough evaluation by the pediatric urologist requires the recognition and knowledge of less-common conditions, including malignancy. Extragonadal germ cell tumors are rare in children aged <15 years, representing approximately 1% of all cancers. Because of the close collaboration between pediatric oncologists and pediatric urologists, a multidisciplinary approach to the management and treatment of these tumors includes chemotherapy and surgical resection, aiming for fertility preservation when possible. We present a 10-month-old infant with a cervical or uterine germ cell tumor and the challenges found during her treatment.

摘要

尽管阴道出血在婴幼儿中是一种不常见的临床表现,但小儿泌尿科医生进行全面评估需要识别和了解包括恶性肿瘤在内的罕见病症。性腺外生殖细胞肿瘤在15岁以下儿童中很少见,约占所有癌症的1%。由于小儿肿瘤学家和小儿泌尿科医生之间的密切合作,对这些肿瘤的管理和治疗采用多学科方法,包括化疗和手术切除,尽可能保留生育能力。我们报告一名10个月大的婴儿患有宫颈或子宫生殖细胞肿瘤以及在其治疗过程中发现的挑战。

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1
Multimodal management of a pediatric cervical yolk sac tumor.小儿宫颈卵黄囊瘤的多模式管理
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Clinical analysis of management of pediatric testicular germ cell tumors.小儿睾丸生殖细胞肿瘤的治疗临床分析。
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Extragonadal Yolk Sac Tumor Limited to the Myometrium: Report of a Case With Potential Fertility Preservation and Molecular Analysis Suggesting Germ Cell Origin.局限于子宫肌层的卵巢外卵黄囊瘤:一例有潜在生育力保存可能的病例报道及提示生殖细胞来源的分子分析。
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引用本文的文献

1
Vaginal yolk sac tumors in infants and children: A case report and literature review.婴幼儿阴道卵黄囊瘤:一例报告及文献复习
Oncol Lett. 2023 Feb 8;25(3):120. doi: 10.3892/ol.2023.13706. eCollection 2023 Mar.
2
Preservation of sexual and reproductive function in the treatment of extragonadal yolk sac tumors in the female genital tract.女性生殖道性腺外卵黄囊瘤治疗中性功能和生殖功能的保留
Front Pediatr. 2022 Nov 14;10:1004501. doi: 10.3389/fped.2022.1004501. eCollection 2022.
3
Use of targeted therapy and immunotherapy for the treatment of yolk sac tumors in extragonadal pelvic sites: two case reports.
靶向治疗和免疫治疗用于治疗性腺外盆腔部位卵黄囊瘤:两例病例报告
Gland Surg. 2021 Oct;10(10):3045-3052. doi: 10.21037/gs-21-663.
4
Yolk sac tumor of vagina: a rare cause of vaginal bleeding in adolescents - a case report.阴道卵黄囊瘤:青少年阴道出血的罕见病因——1 例报告。
Pan Afr Med J. 2020 Oct 16;37:169. doi: 10.11604/pamj.2020.37.169.20949. eCollection 2020.