Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia; Department of Mechanical Engineering, Ege University, 35100 Bornova, Izmir, Turkey.
Advanced Material Research and Development Center, Zhejiang Industry & Trade Vocational College, Wenzhou, Zhejiang 325003, China; Department of Materials Science and Engineering, Jilin University, Changchun, Jilin 130025, China.
Acta Biomater. 2015 Jul;20:176-187. doi: 10.1016/j.actbio.2015.03.023. Epub 2015 Mar 25.
A new series of beta Ti-Nb-Zr (TNZ) alloys with considerable plastic deformation ability during compression test, high elastic admissible strain, and excellent cytocompatibility have been developed for removable bone tissue implant applications. TNZ alloys with nominal compositions of Ti-34Nb-25Zr, Ti-30Nb-32Zr, Ti-28Nb-35.4Zr and Ti-24.8Nb-40.7Zr (wt.% hereafter) were fabricated using the cold-crucible levitation technique, and the effects of alloying element content on their microstructures, mechanical properties (tensile strength, yield strength, compressive yield strength, Young's modulus, elastic energy, toughness, and micro-hardness), and cytocompatibilities were investigated and compared. Microstructural examinations revealed that the TNZ alloys consisted of β phase. The alloy samples displayed excellent ductility with no cracking, or fracturing during compression tests. Their tensile strength, Young's modulus, elongation at rupture, and elastic admissible strain were measured in the ranges of 704-839 MPa, 62-65 GPa, 9.9-14.8% and 1.08-1.31%, respectively. The tensile strength, Young's modulus and elongation at rupture of the Ti-34Nb-25Zr alloy were measured as 839 ± 31.8 MPa, 62 ± 3.6 GPa, and 14.8 ± 1.6%, respectively; this alloy exhibited the elastic admissible strain of approximately 1.31%. Cytocompatibility tests indicated that the cell viability ratios (CVR) of the alloys are greater than those of the control group; thus the TNZ alloys possess excellent cytocompatibility.
已经开发出了一系列具有相当压缩变形能力、高弹性允许应变和出色细胞相容性的新型β Ti-Nb-Zr (TNZ) 合金，可用于可移动骨组织植入物应用。采用冷坩埚悬浮技术制备了名义成分为 Ti-34Nb-25Zr、Ti-30Nb-32Zr、Ti-28Nb-35.4Zr 和 Ti-24.8Nb-40.7Zr（wt.% 以下简称）的 TNZ 合金，并研究和比较了合金元素含量对其微观结构、力学性能（拉伸强度、屈服强度、压缩屈服强度、杨氏模量、弹性能量、韧性和显微硬度）和细胞相容性的影响。微观结构检查表明，TNZ 合金由β 相组成。合金样品在压缩试验中表现出出色的延展性，没有开裂或断裂。它们的拉伸强度、杨氏模量、断裂伸长率和弹性允许应变分别在 704-839 MPa、62-65 GPa、9.9-14.8%和 1.08-1.31%的范围内。Ti-34Nb-25Zr 合金的拉伸强度、杨氏模量和断裂伸长率分别测量为 839 ± 31.8 MPa、62 ± 3.6 GPa 和 14.8 ± 1.6%；该合金表现出约 1.31%的弹性允许应变。细胞相容性测试表明，合金的细胞存活率（CVR）大于对照组；因此，TNZ 合金具有出色的细胞相容性。
