Ma Jianghao, Wang Ying, Liu Yue, Gao Suyu, Ding Liqin, Zhao Feng, Chen Lixia, Qiu Feng
Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Tianjin State Key Laboratory of Modern Chinese Medicine, School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, People's Republic of China.
Fitoterapia. 2015 Jun;103:90-6. doi: 10.1016/j.fitote.2015.03.020. Epub 2015 Mar 24.
Four new cadinane-type sesquiterpenes named phacadinanes A-D (1-4) were isolated from the rhizomes of Curcuma phaeocaulis. Their structures were elucidated by 1D and 2D NMR, as well as accurate mass measurements. Compound 4 was the first example of a rare 4,5-seco-cadinane sesquiterpene isolated from the Zingiberaceae family. Furthermore, inhibitory effects of the isolated compounds on nitric oxide production in LPS-activated macrophages were evaluated. Compounds 1 and 2 showed strong inhibitory activities on NO production with IC50 values of 3.88±0.58 and 2.25±0.71 μM, respectively. A possible biogenetic pathway for 4,5-seco-cadinane sesquiterpene (4) was postulated.
从莪术的根茎中分离出了四种新的杜松烷型倍半萜，命名为莪术杜松烷A-D（1-4）。通过一维和二维核磁共振以及精确质量测量确定了它们的结构。化合物4是从姜科植物中分离出的罕见的4,5-裂杜松烷倍半萜的首个实例。此外，还评估了分离出的化合物对脂多糖激活的巨噬细胞中一氧化氮产生的抑制作用。化合物1和2对一氧化氮的产生表现出强烈的抑制活性，IC50值分别为3.88±0.58和2.25±0.71μM。推测了4,5-裂杜松烷倍半萜（4）可能的生源途径。
